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Rabbit Anti-TYMP Polyclonal Antibody#abs135757

Please note that the price provided above is solely for your reference. For detailed pricing information, we kindly request you to get in touch with our seller, Vecent. Western blot analysis of extracts of various cell lines, using TYMP antibody. This product is for research use only, not for...

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Description

Catalog-specification	Delivery time	USD price
abs135757-100ug	1-2 Weeks	301.0
abs135757-50ug	1-2 Weeks	201.0

Please note that the price provided above is solely for your reference. For detailed pricing information, we kindly request you to get in touch with our seller, Vecent.

Overview
catalog	abs135757
Description	Platelet-derived endothelial cell growth factor (PD-ECGF), also known as thymidine phosphorylase (TP), plays a crucial role in various solid tumors and inflammatory diseases. This intracellular enzyme facilitates the formation of thymine and 2-deoxy-D-ribose-1-phosphate by catalyzing the reaction between thymidine and orthophosphate. Notably, TP exhibits dual functionality, promoting angiogenesis and inhibiting apoptosis. Its angiogenic function heavily relies on its catalytic activity. Unfortunately, an elevated expression of TP/PD-ECGF is often associated with a poor prognosis. This increased expression is commonly observed in different solid tumors and inflammatory diseases. However, it is crucial to note that TP's role extends beyond disease progression. It can also activate fluorouracil derivative (DFUR) prodrugs, enhancing the effectiveness of related treatments for cancer patients. Researchers have extensively explored the potential of targeting TP as a therapeutic strategy for cancer. These studies primarily focus on two approaches: inhibiting TP enzymatic activity or augmenting enzyme induction in combination with DFUR treatment. By either inhibiting TP or boosting its activity, researchers aim to exploit its role in angiogenesis and its ability to enhance the antitumor effects of DFUR-based therapies. In conclusion, thymidine phosphorylase, also known as PD-ECGF, plays a crucial role in promoting angiogenesis and inhibiting apoptosis. Its increased expression in various diseases is often linked to a poor prognosis. However, researchers are actively investigating strategies to target TP in cancer treatment, focusing on inhibiting its enzymatic activity or combining it with DFUR-based therapies to maximize therapeutic outcomes.
Other names	Endothelial cell growth factor 1 (ECGF 1), also known as gliostatin or platelet-derived endothelial cell growth factor, is a crucial protein involved in the growth and development of endothelial cells. It plays a significant role in angiogenesis, the formation of new blood vessels. ECGF 1 is derived from platelets and has been extensively studied for its therapeutic potential in various medical conditions. Another name for ECGF 1 is thymidine phosphorylase (TP) or tymp. TP is an enzyme that catalyzes the conversion of thymidine into thymine and deoxyribose-1-phosphate. This enzyme is crucial in the metabolism of thymidine and is involved in DNA synthesis and repair processes. ECGF 1 has also been linked to certain genetic disorders, such as mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) and mitochondrial DNA depletion syndrome (MTDPS1). These disorders are characterized by abnormalities in mitochondrial function and can result in severe neurological symptoms. Understanding the functions and mechanisms of ECGF 1 and TP is important for advancing medical research and developing targeted therapies. These proteins offer potential therapeutic targets for conditions related to angiogenesis, DNA metabolism, and mitochondrial disorders. Further studies on ECGF 1 and TP may uncover new treatment strategies and improve patient outcomes in various diseases.
Source	Rabbit
Specificity	The TYMP Antibody is designed to detect the total level of endogenous TYMP. This means that the antibody can identify the full amount of TYMP present in a sample, without any interference from external factors. If you need a reliable way to measure TYMP levels, this antibody is a great choice. Just be sure to use it according to the manufacturer's instructions, to ensure accurate and reproducible results.
Species Reactivity	Human;Mouse;Rat
Antigen	TYMP
Application	The dilution ranges for WB, IHC, and ELISA (peptide) are as follows: WB has a dilution range of 1:500-1:2000, IHC has a dilution range of 1:50-1:200, and ELISA (peptide) has a dilution range of 1:20000-1:40000. It is important to accurately dilute the samples within these ranges to ensure optimal results in these experiments.
Immunogen	A synthesized peptide derived from human TYMP.
MW	50kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro.
Celluar localization	Cytosol;
UniPort	P19971