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Rabbit Anti-HEXB Polyclonal Antibody#abs133376

Please note that the price mentioned above is only for your reference. For detailed pricing information, we kindly ask you to get in touch with our seller, Vecent. Western blot analysis of extracts from Jurkat cells, using HEXB antibody. This product is for research use only, not for use in...

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Description

Catalog-specification	Delivery time	USD price
abs133376-100ug	1-2 Weeks	301.0
abs133376-50ug	1-2 Weeks	201.0

Please note that the price mentioned above is only for your reference. For detailed pricing information, we kindly ask you to get in touch with our seller, Vecent.

Overview
catalog	abs133376
Other names	The cervical cancer proto-oncogene 7 protein, also known as beta hexosaminidase beta chain or beta N-acetylhexosaminidase, is a crucial protein involved in various biological processes. It plays a significant role in the degradation of complex carbohydrates and glycolipids. Moreover, it participates in the breakdown of gangliosides, which are important components of cell membranes in the nervous system. This protein is encoded by the HEXB gene and is composed of the beta subunit of beta-hexosaminidase. Often referred to as HCC 7 or HEL 248, this protein is essential for the proper functioning and maintenance of cellular processes. Mutations in the HEXB gene can lead to the development of Tay-Sachs disease, a severe and progressive neurodegenerative disorder. The cervical cancer proto-oncogene 7 protein is also known by its alternative names, including Cervical cancer proto-oncogene 7 protein, ENC 1AS, Epididymis luminal protein 248, and N-acetyl-beta-glucosaminidase subunit beta. These different names reflect the diverse roles and functions of this crucial protein.
Source	Rabbit
Specificity	The HEXB Antibody is capable of identifying and measuring the total amount of endogenous HEXB present in a sample. This means that the antibody is able to detect all forms of HEXB that are naturally produced within the sample.
Species Reactivity	Human;Mouse;Rat
Antigen	HEXB
Application	The recommended dilutions for Western Blot (WB) range from 1:500 to 1:1000. For Immunohistochemistry (IHC), the dilutions range from 1:50 to 1:200. If you are performing Immunofluorescence (IF) or Immunocytochemistry (ICC), the suggested dilutions are between 1:100 and 1:500. Lastly, for Enzyme-Linked Immunosorbent Assay (ELISA) using a peptide as the antigen, the optimal dilutions are 1:20000 to 1:40000. Please note that these dilutions are based on the original text information and rearranged accordingly.
Immunogen	A synthesized peptide.
MW	63 KD
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was employed in the purification process of the antiserum through peptide affinity chromatography. Let me provide you with a rephrased version of the original content, ensuring that the information remains intact: Through the utilization of SulfoLink™ Coupling Resin, the antiserum underwent purification via peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure optimal storage conditions, it is recommended to store the product at a temperature of -20 °C for up to one year. It is important to avoid subjecting the product to repeated freeze/thaw cycles, as this may compromise its integrity and efficacy. Taking these precautions will help to maintain the quality and stability of the product over time.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues.
Posttranslational modification	N-linked glycans at Asn-142 and Asn-190 consist of Man3-GlcNAc2 and Man(5 to 7)-GlcNAc2, respectively.The beta-A and beta-B chains are produced by proteolytic processing of the precursor beta chain.
Celluar localization	Extracellular region or secreted;Lysosome;
UniPort	P07686