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Rabbit Anti-HEXA Polyclonal Antibody#abs136948

Please note that the price mentioned above is provided as a reference only. For detailed pricing information, kindly get in touch with our seller, Vecent. Western blot analysis of extracts of various celllines, using HEXA antibody. This product is for research use only, not for use in diagnostic...

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Description

Catalog-specification	Delivery time	USD price
abs136948-100ug	1-2 Weeks	301.0
abs136948-50ug	1-2 Weeks	201.0

Please note that the price mentioned above is provided as a reference only. For detailed pricing information, kindly get in touch with our seller, Vecent.

Overview
catalog	abs136948
Description	The gene responsible for encoding the alpha subunit of beta-hexosaminidase is crucial for the degradation of GM2 ganglioside and other molecules with N-acetyl hexosamines. The enzyme is composed of two subunits, alpha and beta, which are coded by separate genes. Both subunits belong to family 20 of glycosyl hydrolases. When mutations occur in either subunit, it leads to an accumulation of GM2 ganglioside in neurons and the onset of neurodegenerative disorders referred to as GM2 gangliosidoses. Tay-Sachs disease (GM2-gangliosidosis type I) is the result of alpha subunit gene mutations.
Other names	Alpha chain precursor of beta hexosaminidase; Subunit alpha of beta hexosaminidase; Beta N-acetylhexosaminidase; Subunit alpha of beta N-acetylhexosaminidase; Beta-hexosaminidase A; Alpha subunit of beta-hexosaminidase; Subunit alpha of beta-N-acetylhexosaminidase; Hexa; HEXA_HUMAN; Alpha polypeptide of hexosaminidase A; Hexosaminidase A alpha polypeptide; Hexosaminidase A; Subunit A of hexosaminidase; MGC99608; N-acetyl beta glucosaminidase; Subunit alpha of N-acetyl beta glucosaminidase; Subunit alpha of N-acetyl-beta-glucosaminidase; TSD.
Source	Rabbit
Specificity	The HEXA Antibody is specifically designed to identify and measure the levels of total HEXA protein in its natural form within a biological sample. This highly effective antibody enables researchers to accurately detect the endogenous levels of HEXA protein, providing crucial insights into its cellular presence and activity. By rearranging the original content, but keeping the same information, the following text is generated: Detecting the endogenous levels of total HEXA protein is made possible through the utilization of the HEXA Antibody. This innovative antibody is precisely engineered to target and recognize the natural form of HEXA protein within a biological sample. By using the HEXA Antibody, researchers can reliably measure the levels of HEXA protein present, offering valuable information regarding its cellular abundance and functionality.
Species Reactivity	Human;Mouse;Rat
Antigen	HEXA
Application	The recommended dilution for western blotting is 1:500-1:2000, while for immunohistochemistry it is 1:50-1:200. When it comes to ELISA with peptide, the suggested dilution is 1:20000-1:40000. These dilutions were determined based on extensive testing and optimization to ensure optimal results for each application. It is important to note that variations in sample preparation and experimental conditions may require adjustments to the recommended dilutions. Always perform a titration to determine the optimal dilution for your specific experimental needs.
Immunogen	A synthesized peptide derived from human HEXA.
MW	60kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues. The form B is active against certain oligosaccharides. The form S has no measurable activity.
Posttranslational modification	N-linked glycan at Asn-115 consists of Man3-GlcNAc2.
Celluar localization	Extracellular region or secreted;Lysosome;
UniPort	P06865