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Rabbit Anti-HECW1 Polyclonal Antibody#abs138999

Description

Catalog-specification	Delivery time	USD price
abs138999-100ug	1-2 Weeks	301.0
abs138999-50ug	1-2 Weeks	201.0

Please be advised that the price mentioned above is only for your reference. For detailed pricing information, please get in touch with our seller, Vecent. It's important to note that the generated content should be based on the original text information but rephrased sufficiently to avoid plagiarism. So, kindly refrain from using ChapGPT-generated content and instead, use a language model to create content that is significantly different from the original text.

Overview
catalog	abs138999
Other names	Protein ligase HECW1, also known as HECT, is a C2 and WW domain-containing protein 1. It belongs to the HECT type E3 ubiquitin ligase family and is encoded by the HECW1 gene in humans. This E3 ligase plays a crucial role in the ubiquitination of target proteins. It has been identified as hNEDL1 or NEDD4-like ubiquitin protein ligase 1. Furthermore, it is involved in various cellular processes including protein degradation and signal transduction. The HECW1 protein possesses HECT, C2, and WW domains, which are responsible for its ligase activity. Understanding the function and regulation of HECW1 is important for deciphering the intricate mechanisms of protein modification and turnover in cells.
Source	Rabbit
Specificity	The total HECW1 levels can be detected by the HECW1 antibody, which specifically targets the endogenous expression of HECW1 protein. To create a different version of the content, here's a rearranged statement: The HECW1 antibody is capable of identifying the overall levels of HECW1 protein within the body. This antibody is specifically designed to recognize the endogenous expression of HECW1, enabling researchers to accurately measure its presence.
Species Reactivity	Human
Antigen	HECW1
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human HECW1.
MW	180kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent peptide affinity chromatography to purify it. To create a similar content, the statement is rephrased and rearranged to convey the same message but with different wording.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure optimal storage conditions, it is recommended to store the product at a temperature of -20 °C for a period of one year. It is important to avoid any instances of repeated freeze-thaw cycles, as this can compromise the integrity of the product. By following these guidelines, you can help to ensure that the product remains stable and effective for its intended use.
Storage buffer	The storage conditions for Rabbit IgG are as follows: it should be stored at -20 °C in a solution of phosphate buffered saline with a pH of 7.4. The solution should also contain 150mM NaCl, 0.02% sodium azide, and 50% glycerol. This antibody is stable for a period of 12 months from the date of receipt.
Target
Background	E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS.
Tissue specificity	Predominantly expressed in neurons of adult and fetal brain. Weakly expressed in the kidney.
Celluar localization	Cytosol;
UniPort	Q76N89