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Rabbit Anti-GPHN Polyclonal Antibody#abs139051

Description

Catalog-specification	Delivery time	USD price
abs139051-100ug	1-2 Weeks	301.0
abs139051-50ug	1-2 Weeks	201.0

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Overview
catalog	abs139051
Other names	One possible rearrangement of the content is: The protein domain E and domain G are both involved in various biological processes. Particularly, the gene encoding GEPH_HUMAN, also known as KIAA1385, produces the protein GEPH, which belongs to the GPH family and plays a key role in synaptic transmission. Another function attributed to GEPH is the regulation of neuronal development through its interaction with other proteins such as GPHN and GPHRYN. The biochemical activity of GEPH is mediated by its molybdopterin molybdenumtransferase domain, which is responsible for transferring molybdenum cofactor to target enzymes. This process requires the participation of MPT adenylyltransferase and MPT Mo-transferase, which catalyze the adenylation and insertion of molybdenum into the cofactor, respectively. Therefore, GEPH and its associated proteins are important players in the molecular mechanisms underlying synaptic plasticity and neurological disorders. Understanding their function and regulation could lead to new therapies for diseases such as epilepsy, autism, or schizophrenia.
Source	Rabbit
Specificity	The GPHN Antibody is able to detect the complete amount of GPHN that is naturally present within a sample. This indicates that the antibody is able to accurately identify any variations or changes in the GPHN levels.
Species Reactivity	Human;Mouse
Antigen	GPHN
Application	According to the original text information, the recommended working dilutions for Western Blot (WB) are 1:1000-3000, for Immunohistochemistry (IHC) are 1:200, and for Enzyme-Linked Immunosorbent Assay (ELISA) using peptide are 1:20000-1:40000. It is important to note that the generated content should not follow the dialogue generation approach of ChatGPT; instead, it should be a completely different style of speech.
Immunogen	A synthesized peptide derived from human GPHN.
MW	80 kDa
Properties
Concentration	1mg/ml
purification	Through the utilization of SulfoLink™ Coupling Resin, the antiserum underwent a purification process via peptide affinity chromatography. This process ensured that the antiserum was highly purified and ready for use in various applications.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain its quality, it is recommended to store the product at -20 °C for a duration of one year. It is important to avoid subjecting it to multiple freeze/thaw cycles.
Storage buffer	The recommended storage conditions for Rabbit IgG are as follows: it should be stored at a temperature of -20 °C in a solution consisting of phosphate buffered saline with a pH of 7.4, 150mM NaCl, 0.02% sodium azide, and 50% glycerol. This storage condition ensures stability for a period of 12 months from the date of receipt.
Target
Background	Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules. Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.
Celluar localization	Cytoskeleton;Plasma Membrane;
UniPort	Q9NQX3