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Rabbit Anti-GP9 Polyclonal Antibody#abs136822

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Description

Catalog-specification	Delivery time	USD price
abs136822-100ug	1-2 Weeks	301.0
abs136822-50ug	1-2 Weeks	201.0

Overview
catalog	abs136822
Description	The small membrane glycoprotein encoded by this gene can be found on the surface of human platelets. It plays a crucial role in forming a noncovalent complex with glycoprotein Ib, which functions as a receptor for von Willebrand factor. This receptor complex is composed of the protein encoded by this gene, as well as the alpha and beta subunits and platelet glycoprotein V. Bernard-Soulier syndrome, also known as giant platelet disease, is caused by defects in this gene. Individuals with this syndrome often exhibit abnormally large platelets and experience a clinical tendency to bleed.
Other names	Glycoprotein 9, also known as GP IX or Platelet glycoprotein IX, is a crucial protein involved in platelet function. It is encoded by the CD42a gene and exists in a precursor form called Glycoprotein IX precursor. GP IX is responsible for maintaining platelet adhesion and aggregation, playing a vital role in hemostasis and clot formation. Glycoprotein IX is a type of receptor protein found on the surface of platelets. The interaction between GP IX and other proteins, such as von Willebrand factor and glycoprotein Ib, is essential for platelet tethering and binding to damaged blood vessels. This adhesive function ensures platelet accumulation and initiation of clot formation at the site of injury. The glycosylation of GP IX contributes to its stability and functional activity. GP IX undergoes post-translational modifications, including the addition of carbohydrate molecules, which enhance its receptor activity and ensure proper platelet function. The mature form of GP IX, also known as GPIX, is vital for normal platelet adhesion and aggregation. Abnormalities in GP IX can lead to bleeding disorders, such as Bernard-Soulier syndrome, which is characterized by deficient platelet adhesion and aggregation. Mutations in the CD42a gene can result in the production of dysfunctional or insufficient GP IX, impairing platelet function and causing excessive bleeding. In summary, Glycoprotein IX, encoded by the CD42a gene, is an important protein involved in platelet function. Its glycosylation and interactions with other proteins play a crucial role in platelet adhesion and clot formation. Defects in GP IX can lead to bleeding disorders, highlighting the significance of this glycoprotein in maintaining hemostasis.
Source	Rabbit
Specificity	Endogenous levels of total GP9 can be detected using the GP9 antibody. This antibody is designed to bind to GP9 protein that is naturally occurring within the body. By detecting levels of total GP9, researchers can gain insight into the role this protein plays in various physiological processes. The GP9 antibody works by specifically recognizing the unique signature of the GP9 protein, allowing for accurate and reliable detection. This information can be useful in understanding diseases or conditions that may be associated with altered GP9 levels.
Species Reactivity	Human;Rat
Predictive reaction species	Bovine
Antigen	GP9
Application	The dilution ranges for WB, IHC, and ELISA (peptide) are as follows: WB can be performed at dilutions of 1:500 to 1:2000, while IHC is typically conducted at dilutions of 1:50 to 1:200. For ELISA (peptide), the recommended dilution ranges from 1:20000 to 1:40000. Please note that this information is based on the original text and has been rearranged to provide a similar content.
Immunogen	A synthesized peptide derived from human GP9.
MW	37kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was used to purify the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib.
Celluar localization	Plasma Membrane;
UniPort	P14770