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Rabbit Anti-FATP1 Polyclonal Antibody#abs137193

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Description

Catalog-specification	Delivery time	USD price
abs137193-100ug	1-2 Weeks	301.0
abs137193-50ug	1-2 Weeks	201.0

Overview
catalog	abs137193
Other names	Fatty acid transport protein 1, also known as FATP1 or SLC27A1, is an important member of the solute carrier family 27 (fatty acid transporter). This protein, encoded by the genes ACSVL5, FLJ00336, and MGC71751, plays a crucial role in the transport of long-chain fatty acids. FATP1 is responsible for facilitating the uptake of fatty acids into cells, where they can be utilized for various metabolic processes. This protein is predominantly found in tissues with high energy demands, such as the liver, heart, and skeletal muscle. Research has shown that mutations in FATP1 can lead to impaired fatty acid uptake, resulting in metabolic disorders such as insulin resistance and obesity. Understanding the function and regulation of FATP1 is vital for gaining insights into metabolic diseases and developing targeted therapies. In summary, FATP1, also known as fatty acid transport protein 1, is a key player in the transport of long-chain fatty acids. Its importance in cellular metabolism and energy homeostasis makes it a promising target for future studies and therapeutic interventions.
Source	Rabbit
Specificity	The FATP1 Antibody is capable of identifying the entirety of endogenous FATP1 levels. This means that it can detecting all the forms of this protein that are naturally occurring within the system.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Chicken;Sheep;Dog;Bovine;
Antigen	FATP1
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human FATP1.
MW	65 kDa
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography using SulfoLink™ Coupling Resin was employed to purify the antiserum. Request for a different approach to generate content or speech that is substantially different from the original text.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain its quality, it is advisable to store the product at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting it to repeated freeze/thaw cycles, as it may affect its efficacy.
Storage buffer	To preserve the quality of Rabbit IgG, it must be stored at a temperature of -20 °C. The IgG should be kept in phosphate buffered saline that has a pH level of 7.4, with 150mM NaCl. Additionally, it contains 0.02% sodium azide and 50% glycerol to prevent degradation and ensure stability. This storage condition guarantees a shelf life of 12 months from the date of purchase.
Target
Background	Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. The LFCA import appears to be hormone-regulated in a tissue-specific manner. In adipocytes, but not myocytes, insulin induces a rapid translocation of FATP1 from intracellular compartments to the plasma membrane, paralleled by increased LFCA uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LFCA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (By similarity).
Tissue specificity	Highest levels of expression are detected in muscle and adipose tissue small, intermediate levels in small intestine, and barely detectable in liver.
Celluar localization	Endoplasmic reticulum;Plasma Membrane;
UniPort	Q6PCB7