Rabbit Anti-Collagen XXV Alpha1 Polyclonal Antibody#abs140635
Please note that the mentioned price is for your information only. For the detailed price, we kindly request you to get in touch with our sales representative, Vecent. Western blot analysis of extracts from Jurkat cells and A549 cells, using Collagen XXV antibody. This product is for research...
Description
| Catalog-specification | Delivery time | USD price |
abs140635-100ug | 1-2 Weeks | 301.0 |
abs140635-50ug | 1-2 Weeks | 201.0 |
Please note that the mentioned price is for your information only. For the detailed price, we kindly request you to get in touch with our sales representative, Vecent.
| Overview | |
catalog | abs140635 |
| Other names | The Alzheimer disease amyloid-associated protein, also known as AMY, is a crucial component of the amyloid plaque present in the brains of Alzheimer's disease patients. This protein was previously known as CLAC, which stands for collagen-like Alzheimer amyloid plaque component. CLAC is the precursor to CLAC-P, and both are involved in the formation of amyloid plaques. In addition to its role in Alzheimer's disease, the COL25A1 protein, also known as collagen alpha 1 XXV chain, is involved in the formation of collagen, which is a crucial component of connective tissues in the body. It is also involved in the development and maintenance of the central nervous system. Studies have suggested that abnormalities in the production of CLAC and COL25A1 may play a role in the development of Alzheimer's disease. Therefore, understanding the complex interactions between these proteins and the brain's neural networks could potentially lead to new therapies for this devastating disease. |
| Source | Rabbit |
| Specificity | The detection of endogenous levels of total Collagen XXV α1 is facilitated by the Collagen XXV α1 Antibody. The antibody is specifically designed to recognize and bind to Collagen XXV α1, allowing for the accurate measurement of its presence. By targeting this protein, researchers can assess the abundance of Collagen XXV α1 in a biological sample, providing valuable insights into its role and function. This antibody offers a reliable tool for studying Collagen XXV α1 and its involvement in various physiological processes. |
| Species Reactivity | Human;Mouse |
| Predictive reaction species | Rabbit;Pig; |
| Antigen | Collagen XXV alpha1 |
| Application | The dilution range for Western Blot (WB) is typically 1:500 to 1:1000. For Immunofluorescence (IF) or Immunocytochemistry (ICC), the dilution range is usually 1:100 to 1:500. In ELISA assays using peptides, the recommended dilution range is 1:20000 to 1:40000. These dilution ranges are essential for optimal experimental results and accurate detection of the target proteins. |
| Immunogen | A synthesized peptide. |
| MW | 64 KD |
| Properties | |
Concentration | 1mg/ml |
| purification | SulfoLinkâ„¢ Coupling Resin was utilized in the purification process of the antiserum through peptide affinity chromatography. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | To ensure the integrity of the product, it is recommended to store it at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the product to multiple freeze/thaw cycles. |
| Storage buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
Target | |
Background | Inhibits fibrillization of amyloid-beta peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin. |
| Tissue specificity | Expressed predominantly in brain. Deposited preferentially in primitive or neuritic amyloid plaques which are typical of Alzheimer disease. |
| Posttranslational modification | Undergoes proteolytic cleavage by furin protease to yield the soluble collagen-like Alzheimer amyloid plaque component.Glycosylated.Hydroxylated on 11% of proline residues and 49% of lysine residues. |
| Celluar localization | Endoplasmic reticulum;Extracellular region or secreted;Plasma Membrane; |
| UniPort | Q9BXS0 |
Western blot analysis of extracts from Jurkat cells and A549 cells, using Collagen XXV antibody.
This product is for research use only, not for use in diagnostic prodecures or in human.
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