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Rabbit Anti-ENO2 Polyclonal Antibody#abs136715

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Description

Catalog-specification	Delivery time	USD price
abs136715-50ug	1-2 Weeks	201.0
abs136715-100ug	1-2 Weeks	301.0

Overview
catalog	abs136715
Description	The mammalian body contains three enolase isoenzymes, and this gene is responsible for one of them. This particular isoenzyme, which forms a homodimer, is present in mature neurons and related cells. During development in primates and rats, neural tissues experience a transition from alpha enolase to gamma enolase. In addition to being neurotrophic, it has neuroprotective properties that are beneficial to several central nervous system (CNS) neurons. Cultured neocortical neurons can bind to it in a calcium-dependent manner, and it facilitates cell survival.
Other names	Enolase 2, also known as 2 phospho D glycerate hydrolyase or 2-phospho-D-glycerate hydro-lyase, is a vital enzyme found in various tissues, including neurons, muscles, and erythrocytes. It exists in several isoforms, including gamma enolase, neuronal-specific enolase, and neurone specific enolase, among others. Enolase 2 plays a crucial role in carbohydrate metabolism by catalyzing the conversion of 2-phosphoglycerate to phosphoenolpyruvate. In addition to its metabolic function, this enzyme also has non-metabolic roles, including acting as a plasminogen receptor, influencing cell differentiation, and participating in various signaling pathways. Recent studies have also linked enolase 2 to various diseases, including cancer, Alzheimer's disease, and autoimmune diseases. It is a potential biomarker for several pathological conditions, and its activity level may indicate the severity of the disease. Overall, enolase 2 is an essential enzyme with multiple functions that play a crucial role in maintaining cellular homeostasis. Its diverse functions make it a potential target for therapeutic interventions and a useful diagnostic tool for various diseases.
Source	Rabbit
Specificity	The ENO2 Antibody is designed to recognize and measure the levels of total ENO2 protein present in the body. Its purpose is to detect the endogenous expression of ENO2 and provide valuable information about its abundance.
Species Reactivity	Human;Mouse;Rat
Antigen	ENO2
Application	For Western blotting, the recommended dilution range of primary antibody is 1:500-1:2000. When performing immunofluorescence or immunocytochemistry, a dilution range of 1:100-1:500 is recommended. For an ELISA assay with peptide, a dilution range of 1:20000-1:40000 is recommended. It is important to follow the recommended dilution range to achieve accurate and reliable results in your experiments.
Immunogen	A synthetic peptide of humanENO2.
MW	47kDa
Properties
Concentration	1mg/ml
purification	The SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography in order to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity).
Tissue specificity	The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons.
Celluar localization	Cytosol;Extracellular region or secreted;Plasma Membrane;
UniPort	P09104