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Rabbit Anti-CROCC Polyclonal Antibody#abs139396

Please note that the given price is only for your reference. For detailed pricing information, we kindly request you to get in touch with our seller, Vecent. Western blot analysis CROCC using COLO205 whole cell lysates This product is for research use only, not for use in diagnostic prodecures...

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Description

Catalog-specification	Delivery time	USD price
abs139396-100ug	1-2 Weeks	301.0
abs139396-50ug	1-2 Weeks	201.0

Please note that the given price is only for your reference. For detailed pricing information, we kindly request you to get in touch with our seller, Vecent.

Overview
catalog	abs139396
Other names	Rootletin, also known as Ciliary Rootlet Coiled-Coil Protein (Crocc) or KIAA0445, is a protein that forms a coiled coil structure in the ciliary rootlet. It is encoded by the CROCC_HUMAN gene. Rootletin plays a crucial role in the formation and maintenance of the ciliary rootlet, a cytoskeletal structure found in ciliated cells. The coiled coil structure of Rootletin provides stability and structural support to the ciliary rootlet. Understanding the function of Rootletin is important for gaining insights into the organization and function of cilia, which are involved in various cellular processes including signal transduction and motility. Further research on Rootletin may contribute to our understanding of ciliary biology and its implications in human health and disease.
Source	Rabbit
Specificity	The detection of total CROCC at endogenous levels can be accomplished using the CROCC Antibody. This antibody is designed to recognize and bind to CROCC protein that is produced by an organism at normal levels.
Species Reactivity	Human;Mouse
Antigen	CROCC
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human CROCC.
MW	229 kDa
Properties
Concentration	1mg/ml
purification	Using the SulfoLink™ Coupling Resin, the purification process for the antiserum involved peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the integrity of the product, it is recommended to store it at -20 °C for a duration of one year. It is important to avoid subjecting the product to multiple freeze/thaw cycles as this can cause potential damage.
Storage buffer	The storage condition for Rabbit IgG is at -20 °C in a solution containing phosphate buffered saline with a pH of 7.4. The solution also includes 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It remains stable for a period of 12 months starting from the date of receipt.
Target
Background	The ciliary rootlet, a cytoskeletal-like structure found in ciliated cells, plays a crucial role in cell function. It emerges from the basal body near the base of the cilium and extends towards the cell nucleus. This structural component is vital for the proper positioning of the basal body in relation to the nucleus, which is necessary for ciliogenesis, the formation of cilia. Moreover, it also contributes to the cohesion of the centrosome, a cellular organelle, before the process of mitosis. These functions highlight the importance of the ciliary rootlet in maintaining cellular organization and facilitating essential cellular processes. Research suggests its similarity to other structural components and its involvement in various cellular activities. The understanding of its role and mechanisms aids in unraveling the complexities of cellular biology.
Posttranslational modification	Phosphorylated by NEK2 which may regulate its association with centrosomes.
Celluar localization	Cytoskeleton;Cytosol;Extracellular region or secreted;Plasma Membrane;
UniPort	Q5TZA2