Home - Products - Antibodies - Primary Antibodies - Polyclonal Antibody - Details

Rabbit Anti-CRFR2 Polyclonal Antibody#abs131402

Please note that the price mentioned above is only for reference purposes. For detailed pricing information, please reach out to our seller Vecent. It is important to keep in mind that the generated content is based on the original text information, so please avoid following the same style as...

Send Inquiry

Description

Catalog-specification	Delivery time	USD price
abs131402-100ug	1-2 Weeks	301.0
abs131402-50ug	1-2 Weeks	201.0

Overview
catalog	abs131402
Description	This receptor displays a strong binding affinity for corticotropin releasing factor and is also capable of binding to urocortin I, II, and III. It primarily functions through the activation of G proteins, which subsequently activate adenylyl cyclase. By rearranging the provided information, a highly similar content can be generated. However, it is important to note that I will not generate content in a completely different manner as per your request.
Other names	This is a list of various names referring to the same protein - the corticotropin releasing hormone receptor 2. Other names include corticotropin-releasing factor receptor 2, CRF 2, CRF R2, CRF RB, CRF-R-2, CRF-R2, CRF2, CRF2 receptor beta isoform, CRF2R, CRFR 2, CRFR-2, CRFR2, CRFR2_HUMAN, CRH 2R, CRH R2, CRH-R-2, CRH-R2, CRH2R, CRHR 2, and hm CRF. Despite all these different labels, they all refer to the same protein which plays an important role in regulating stress and anxiety responses in the body.
Source	Rabbit
Specificity	This antibody, CRFR2 Antibody, has the ability to identify total CRFR2 at its natural levels. The endogenous levels of CRFR2 can be detected by using this antibody.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Sheep;Dog;Horse;
Antigen	CRFR2
Application	The dilutions for Western blotting (WB) range from 1:500 to 1:2000. For immunohistochemistry (IHC), the dilutions would be 1:50 to 1:200. When it comes to immunofluorescence/immunocytochemistry (IF/ICC), the appropriate dilutions are 1:100 to 1:500. For ELISA with peptide detection, the dilutions would be 1:20000 to 1:40000. It is important to ensure these dilutions are accurate for reliable experimental results.
Immunogen	A synthesized peptide derived from human CRFR2.
MW	48 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography in order to purify the antiserum. Let me provide you with a rephrased version of the original content, maintaining its key information. Please note that the generated content is simply a paraphrased version. The purification of the antiserum involved employing SulfoLink™ Coupling Resin for peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.
Posttranslational modification	A N-glycosylation site within the signal peptide impedes its proper cleavage and function.
Celluar localization	Plasma Membrane;
UniPort	Q13324