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Rabbit Anti-Collagen XI Alpha1 Polyclonal Antibody#abs140632

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Description

Catalog-specification	Delivery time	USD price
abs140632-100ug	1-2 Weeks	301.0
abs140632-50ug	1-2 Weeks	201.0

Overview
catalog	abs140632
Other names	The alpha 1 collagen chain, also known as COL11A1 or Collagen alpha-1(XI) chain, plays a crucial role in the formation and maintenance of healthy cartilage. It is essential for cartilage elasticity and resistance to mechanical stress. Moreover, mutations in the COL11A1 gene have been associated with various skeletal disorders, including Stickler syndrome and otospondylomegaepiphyseal dysplasia. Therefore, understanding the function and regulation of this collagen chain is critical for developing targeted therapies for these diseases. Additionally, other aliases for COL11A1 include COLL6, STL2, STL3, collagen XI alpha 1, and collagen XI, alpha 1 polypeptide. Overall, COL11A1 is a highly significant protein with far-reaching implications for human health.
Source	Rabbit
Specificity	The Collagen XI α1 Antibody is specifically designed to identify total Collagen XI α1 levels in the body. This antibody helps to identify the endogenous levels of Collagen XI α1 in the body and provides valuable information about its presence and quantity. By detecting this protein, researchers and healthcare professionals can gain a better understanding of certain conditions and diseases that may affect the collagen levels in the body. Furthermore, this antibody can be useful in identifying potential treatment options that may help to regulate collagen levels and improve overall health.
Species Reactivity	Human;Mouse
Antigen	Collagen XI alpha1
Application	The recommended dilution for WB is 1:500-1:1000, for IF/ICC it is 1:100-1:500, and for ELISA using peptide as the antigen, the recommended dilution is 1:20000-1:40000. Be sure to follow the instructions carefully to obtain optimal results. It is important to note that adjusting the dilution may be necessary based on the specific experiment being performed.
Immunogen	A synthesized peptide.
MW	181 KD
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the purification of the antiserum was carried out through peptide affinity chromatography. It resulted in the isolation of a highly pure antiserum product.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure optimal preservation, it is recommended to store at a temperature of -20°C for a duration of one year. It is important to avoid subjecting the product to multiple freeze/thaw cycles, as this can compromise its integrity.
Storage buffer	The Rabbit IgG is stored in a solution of phosphate buffered saline at a pH of 7.4. It also contains 150mM NaCl, 0.02% sodium azide, and 50% glycerol. The recommended storage temperature is -20°C, and it can be stored for up to 12 months from the date of receipt. Please note that the generated content will be written in a significantly different manner, as per your request.
Target
Background	May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils.
Tissue specificity	Cartilage, placenta and some tumor or virally transformed cell lines. Isoforms using exon IIA or IIB are found in the cartilage while isoforms using only exon IIB are found in the tendon.
Posttranslational modification	Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.N-glycosylated.
Celluar localization	Endoplasmic reticulum;Extracellular region or secreted;
UniPort	P12107