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Rabbit Anti-CIDEC Polyclonal Antibody#abs138433

Description

Catalog-specification	Delivery time	USD price
abs138433-100ug	1-2 Weeks	301.0
abs138433-50ug	1-2 Weeks	201.0

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Overview
catalog	abs138433
Other names	CIDE-3, also known as cell death activator or cell death inducing DFFA like effector C, is a protein that plays a crucial role in cell death. It is responsible for the activation of programmed cell death, which is essential for maintaining the body's physiological balance. CIDEC, or cell death-inducing DFFA-like effector protein C, is another name for CIDE-3. It is also known as fat-specific protein FSP27 homolog and is associated with the development of certain types of obesity, such as familial partial lipodystrophy type 5 (FPLD5). FSP27, or fat-specific protein 27, is another name for CIDEC. It is a protein that is predominantly found in adipose tissue and is involved in lipid droplet formation and regulation, which is crucial for maintaining energy balance in the body. Although CIDE-3, CIDEC, and FSP27 are known by different names, they are essentially the same protein with similar functions. Together, they play a vital role in maintaining the body's balance and preventing the risk of disease. Understanding their functions and activities is essential in advancing research into obesity, cell death, and related conditions.
Source	Rabbit
Specificity	Detecting endogenous levels of total CIDEC, the CIDEC Antibody is designed to accurately measure the presence of CIDEC protein. The antibody can specifically identify and bind to CIDEC, allowing for the detection and quantification of CIDEC levels within cells or tissues. This highly sensitive antibody enables researchers to investigate the expression and regulation of CIDEC in various biological systems. By detecting endogenous CIDEC, this antibody provides valuable insights into the role and function of CIDEC in cellular processes.
Species Reactivity	Human
Antigen	CIDEC
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human CIDEC.
MW	26 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. An effective method for purifying the antiserum, this process was highly efficient in producing a pure and potent substance.
Clonality	Polyclonal Antibody
Stability & Storage	To prevent damage, it is recommended to keep the item at a temperature of -20 °C for a duration of one year. Please ensure that there are no repeated freeze/thaw cycles during this time.
Storage buffer	This product contains Rabbit IgG in a solution of phosphate buffered saline with a pH of 7.4 and 150mM of NaCl. Additionally, it contains 0.02% sodium azide and 50% glycerol. For optimal storage, this product should be kept at -20 °C, and it will remain stable for up to 12 months after the date of receipt.
Target
Background	Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair. Its role in neutral lipid transfer and lipid droplet enlargement is activated by the interaction with PLIN1. May act as a CEBPB coactivator in the white adipose tissue to control the expression of a subset of CEBPB downstream target genes, including SOCS1, SOCS3, TGFB1, TGFBR1, ID2 and XDH. When overexpressed in preadipocytes, induces apoptosis or increases cell susceptibility to apoptosis induced by serum deprivation or TGFB treatment. As mature adipocytes, that express high CIDEC levels, are quite resistant to apoptotic stimuli, the physiological significance of its role in apoptosis is unclear. May play a role in the modulation of the response to osmotic stress by preventing NFAT5 to translocate into the nucleus and activate its target genes expression.
Tissue specificity	Expressed mainly in adipose tissue, small intestine, heart, colon and stomach and, at lower levels, in brain, kidney and liver.
Posttranslational modification	Ubiquitinated and targeted to proteasomal degradation, resulting in a short half-life. Protein stability depends on triaclyglycerol synthesis, fatty acid availability and lipid droplet formation (By similarity).
Celluar localization	Cytosol;Endoplasmic reticulum;Nucleus;
UniPort	Q96AQ7