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Rabbit Anti-CHAC1 Polyclonal Antibody#abs138873

Description

Catalog-specification	Delivery time	USD price
abs138873-100ug	1-2 Weeks	301.0
abs138873-50ug	1-2 Weeks	201.0

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Overview
catalog	abs138873
Other names	The protein known as Notch is blocked by a substance called Botch. Another protein, known as Cation Transport Regulator Like Protein 1 (CTL1) or ChaC cation transport regulator homolog 1, also has a similar effect. This protein has other names, including Cation Transport Regulator-Like Protein 1 and ChaC cation transport regulator like 1. It is also known as Gamma GCT Acting on Glutathione Homolog 1 or Gamma-GCG 1. Additionally, it is referred to as Glutathione-Specific Gamma-Glutamylcyclotransferase 1. Overall, it plays a role in regulating the transport of cations and has been shown to act on glutathione as well.
Source	Rabbit
Specificity	The CHAC1 Antibody has the ability to identify the complete levels of CHAC1 that are present within an organism. This antibody works by detecting the proteins that are naturally produced by the body in order to locate the presence of CHAC1. By using this antibody, it is possible to gain insights into the levels of CHAC1 present in the body and to monitor changes in these levels over time. With its high level of specificity and sensitivity, the CHAC1 Antibody is a valuable tool for researchers and clinicians who are studying the role of CHAC1 in various biological processes.
Species Reactivity	Human
Predictive reaction species	Pig;Rabbit;Sheep;Dog;Bovine;Horse;
Antigen	CHAC1
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human CHAC1.
MW	29kDa
Properties
Concentration	1mg/ml
purification	The purification of the antiserum employed SulfoLink™ Coupling Resin for peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure the longevity of the product, it is recommended to store it at a temperature of -20 °C for a duration of one year. It is crucial to avoid subjecting the product to repeated cycles of freezing and thawing, as it can alter its quality and compromise its efficacy.
Storage buffer	The recommended storage condition for Rabbit IgG is at -20 °C in a solution of phosphate buffered saline with a pH of 7.4. The solution should also contain 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is advised to store the product under these conditions for a period of 12 months from the date of receipt to ensure stability.
Target
Background	Catalyzes the cleavage glutathione into 5-oxoproline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Glutathione depletion is an important factor for apoptosis initiation and execution (PubMed:23070364). Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade (PubMed:19109178). Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos (PubMed:22445366).
Tissue specificity	Induced by chemical activators of the unfolded protein response (UPR) such as tunicamycin, DTT and thapsigargin.
Celluar localization	Cytosol;Golgi apparatus;
UniPort	Q9BUX1