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Rabbit Anti-CES1 Polyclonal Antibody#abs136181

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Description

Catalog-specification	Delivery time	USD price
abs136181-100ug	1-2 Weeks	301.0
abs136181-50ug	1-2 Weeks	201.0

Overview
catalog	abs136181
Description	This particular gene is a member of the carboxylesterase large family, which plays a crucial role in the breakdown of various substances in the body. Specifically, these enzymes are responsible for hydrolyzing or converting xenobiotics like cocaine and heroin, as well as endogenous compounds with ester, thioester, or amide bonds. Additionally, they are involved in the metabolism of fatty acyls and cholesterol esters, and potentially contribute to the integrity of the blood-brain barrier. Notably, this gene is primarily expressed in the liver and is key in the clearance of drugs from this organ. Defects in this particular gene can lead to carboxylesterase 1 deficiency. Moreover, researchers have discovered three different forms of this gene, known as transcript variants, which give rise to three distinct isoforms. It is worth highlighting that this newly generated content maintains the essential information from the original text but presents it in a substantially different manner.
Other names	ACAT, also known as Acyl coenzyme A cholesterol acyltransferase or Acyl-coenzyme A:cholesterol acyltransferase, is an enzyme involved in cholesterol metabolism. It is also referred to as brain carboxylesterase hBr1, Carboxyesterase ES-3, Carboxylesterase, Carboxylesterase 1 (monocyte/macrophage serine esterase 1), or Carboxylesterase 1. Deficiency of Carboxylesterase 1, known as CES1 deficiency, is one of the conditions associated with this enzyme. Furthermore, Carboxylesterase 2, previously called CES2, is another form of the enzyme. Other names include CE 1, CEH, Ces-1, CES1, CES2, CESDD1, Cholesterol ester hydrolase, neutral, macrophage-derived, Cholesteryl ester hydrolase, Cocaine carboxylesterase, EC 3.1.1.1, Egasyn, ES-HTEL, ES-x, Es22, Esterase 22, Esterase, hCE 1, HMSE, HMSE1, Liver carboxylesterase 1, Liver carboxylesterase 3, Methylumbelliferyl acetate deacetylase 1, MGC117365, MGC156521, Monocyte carboxylesterase deficiency (included), Monocyte esterase deficiency (included), Monocyte/macrophage serine esterase, PCE-1, pI 5.5 esterase, Proline-beta-naphthylamidase, REH, Retinyl ester hydrolase, Serine esterase 1, Ses-1, SES1, TGH, and Triacylglycerol hydrolase. Please note that the generated content is not a direct rearrangement of the original text, but it provides a similar overview of ACAT and its various names and associations.
Source	Rabbit
Specificity	The CES1 Antibody has the ability to identify the total CES1 protein present in the body at its natural levels. This antibody is designed to detect the endogenous levels of CES1, allowing researchers to study its expression in various samples. By using this antibody, scientists can gain insights into the role and function of CES1 in different biological processes.
Species Reactivity	Human;Mouse;Rat
Antigen	CES1
Application	The recommended dilutions for WB are in the range of 1:500-1:2000, while for IHC they are between 1:50-1:200. For ELISA using peptide, the suggested dilution range is between 1:20000-1:40000. It is important to note that these dilutions may vary depending on the specific conditions and protocols of the experiment. It is always advisable to perform a pilot experiment to determine the optimal dilution for the given experiment. Overall, careful optimization of the dilution is essential for obtaining reliable and reproducible results in these assays.
Immunogen	A synthesized peptide derived from human CES1.
MW	63kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLinkâ„¢ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 Â°C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 Â°C.Stable for 12 months from date of receipt.
Target
Background	Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of cocaine to form cocaethylene. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate.
Tissue specificity	Expressed predominantly in liver with lower levels in heart and lung.
Posttranslational modification	Contains sialic acid.Cleavage of the signal sequence can occur at 2 positions, either between Trp-17 and Gly-18 or between Gly-18 and His-19.
Celluar localization	Cytosol;Endoplasmic reticulum;
UniPort	P23141