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Rabbit Anti-CD248 Polyclonal Antibody#abs139020

Please note that the price mentioned above is only for your reference. For detailed pricing information, please get in touch with our sales representative, Vecent. Western blot analysis CD248 using COLO205 whole cell lysates This product is for research use only, not for use in diagnostic...

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Description

Catalog-specification	Delivery time	USD price
abs139020-100ug	1-2 Weeks	301.0
abs139020-50ug	1-2 Weeks	201.0

Please note that the price mentioned above is only for your reference. For detailed pricing information, please get in touch with our sales representative, Vecent.

Overview
catalog	abs139020
Other names	Endosialin, also known as CD164 sialomucin like 1, CD164L1, CD248, CD248 antigen, TEM1, or Tumor endothelial marker 1, is a sialomucin-like transmembrane glycoprotein that is highly expressed in tumor vasculature. It plays a crucial role in angiogenesis, proliferation, migration, and differentiation of endothelial cells. Endosialin is a promising target for anti-angiogenic therapies, as it is selectively expressed on tumor endothelium and not on normal blood vessels. Research has shown that endosialin inhibition can lead to decreased tumor growth and improved anti-tumor immunity. Understanding the functions and mechanisms of endosialin may provide new insights into cancer biology and lead to the development of novel cancer treatments.
Source	Rabbit
Specificity	The detection of endogenous levels of total CD248 is possible with the use of CD248 Antibody. By rearranging the provided information, I have generated content that conveys the same meaning while using different words and sentence structure.
Species Reactivity	Human;Mouse
Predictive reaction species	Xenopus;Rabbit;Pig;Dog;Sheep;Bovine;
Antigen	CD248
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human CD248.
MW	81 kDa
Properties
Concentration	1mg/ml
purification	The SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography to purify the antiserum. We were able to obtain a highly purified antiserum thanks to this technique.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality, it is recommended to store the item at a temperature of -20 °C for a duration of one year. It is crucial to prevent exposing the item to multiple freeze and thaw cycles.
Storage buffer	- The storage conditions for Rabbit IgG are at -20°C in a solution of phosphate buffered saline, pH 7.4, containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is important to note that the stability of Rabbit IgG is guaranteed for a duration of 12 months from the date of receipt. Please ensure proper storage and handling to maintain its efficacy.
Target
Background	May play a role in tumor angiogenesis.
Tissue specificity	Expressed in tumor endothelial cells but absent or barely detectable in normal endothelial cells. Expressed in metastatic lesions of the liver and during angiogenesis of corpus luteum formation and wound healing. Expressed in vascular endothelial cells of malignant tumors but not in normal blood vessels. Expressed in stromal fibroblasts.
Posttranslational modification	O-glycosylated with sialylated oligosaccharides.May be N-glycosylated.
Celluar localization	Extracellular region or secreted;
UniPort	Q9HCU0