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Rabbit Anti-CCNB1IP1 Polyclonal Antibody#abs141095

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Description

Catalog-specification	Delivery time	USD price
abs141095-100ug	1-2 Weeks	301.0
abs141095-50ug	1-2 Weeks	201.0

Overview
catalog	abs141095
Other names	The gene C14orf18, also known as Cyclin B1 interacting protein 1 (CCNB1IP1) or enhancer of invasion 10 (HEI10), is located on chromosome 14 and encodes for an E3 ubiquitin protein ligase. CCNB1IP1 is a critical player in the cell cycle, specifically in regulating the activity of cyclin B1. It has also been shown to be involved in DNA repair and meiotic recombination. Additionally, CCNB1IP1 has been linked to cancer, as its overexpression can lead to increased cell proliferation and tumor growth. The protein has also been given other names such as Human enhancer of invasion 10 (HEI10), and mei4. The human gene Gm288 also encodes for CCNB1IP1.
Source	Rabbit
Specificity	The CCNB1IP1 Antibody is capable of detecting the total levels of endogenous CCNB1IP1 in various cell lines and tissues. This means that the antibody is designed to specifically target and identify CCNB1IP1 protein, which is present in biological samples at varying levels. The antibody serves as a useful tool for researchers and scientists to accurately measure CCNB1IP1 levels and study its biological functions in various contexts.
Species Reactivity	Human
Antigen	CCNB1IP1
Application	1:500~1:1000，/1:100-1:500，（）1:20000-1:40000。。
Immunogen	A synthesized peptide.
MW	32 KD
Properties
Concentration	1mg/ml
purification	The SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography in order to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it is recommended to store it at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the product to multiple freezing and thawing cycles.
Storage buffer	The storage guidelines for Rabbit IgG are as follows: It should be stored at a temperature of -20 °C in a solution containing phosphate buffered saline with a pH of 7.4, 150mM NaCl, 0.02% sodium azide, and 50% glycerol. The stability of the product is guaranteed for a period of 12 months from the date of purchase. It is important to adhere to these guidelines to maintain the integrity and effectiveness of the Rabbit IgG.
Target
Background	Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over (By similarity). Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.
Tissue specificity	Highly expressed in heart. Detected at intermediate levels in liver and kidney, and at low levels in placenta, brain and lung.
Posttranslational modification	Ubiquitinated; autoubiquitinated.Phosphorylated by CDK1 on serine or threonine residues (in vitro).
Celluar localization	Nucleus;
UniPort	Q9NPC3