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Rabbit Anti-Histamine H4 Receptor Polyclonal Antibody#abs140440

Rabbit Anti-Histamine H4 Receptor Polyclonal Antibody#abs140440

Please note that the mentioned price is only for your reference. For detailed pricing information, kindly get in touch with our seller, Vecent. Western blot analysis Histamine H4 Receptor using K562 whole cell lysates This product is for research use only, not for use in diagnostic prodecures or...

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Description

Catalog-specificationDelivery timeUSD price

abs140440-100ug

1-2 Weeks

301.0

abs140440-50ug

1-2 Weeks

201.0

Please note that the mentioned price is only for your reference. For detailed pricing information, kindly get in touch with our seller, Vecent.


Overview

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abs140440
Other namesThe Histamine H4 receptor, also known as HRH4 or H4R, is a key G protein coupled receptor 105 that plays a crucial role in various physiological and pathological processes. Its gene is encoded by the GPRv53 and Pfi-013 genes, and it is primarily expressed in immune cells, such as eosinophils, mast cells, and T cells. The receptor's activation leads to the modulation of different signaling pathways, including intracellular calcium mobilization and the activation of phospholipase C. The HH4R also acts as a mediator of histamine-induced inflammation, making it a potential therapeutic target for various inflammatory diseases such as allergies, asthma, and dermatitis. The receptor's critical function and ubiquitous presence in immune cells make it an essential molecule in the regulation of immune responses.
SourceRabbit
SpecificityThe antibody for Histamine H4 Receptor can effectively detect the total levels of endogenous expression of this receptor in the human body. This means that the accurate measurement of Histamine H4 Receptor can be attained with this highly efficient antibody.
Species ReactivityHuman
AntigenHistamine H4 Receptor
ApplicationThe recommended dilutions for WB, IHC and ELISA(peptide) are 1:1000, 1:200 and 1:20000-1:40000 respectively. It is important to adhere to the recommended dilutions to obtain accurate results. The WB dilution is ideal for detecting protein expression levels, while the IHC dilution is suitable for detecting protein localization in tissue sections. The ELISA (peptide) dilution range is suitable for detecting specific peptides in biological samples. It is important to optimize the dilution concentrations for each assay to obtain the most reliable and reproducible results.
ImmunogenA recently developed compound, derived from the Histamine H4 Receptor found in humans, is a synthesized peptide. It has been meticulously created to maintain a high level of similarity to the original protein sequence. Such innovative peptides have paved the way for various scientific advancements, ushering in new possibilities for research and therapeutic interventions. By leveraging the inherent properties of the human Histamine H4 Receptor, this synthesized peptide holds tremendous potential in unraveling intricate mechanisms and understanding complex physiological processes. Its composition, carefully based on the original text information, ensures a robust foundation for further investigations and applications in biomedical sciences.
MW45kDa
Properties

Concentration

1mg/ml

purificationSulfoLink™ Coupling Resin was employed for the purification of the antiserum through peptide affinity chromatography.
ClonalityPolyclonal Antibody
Stability & StorageTo ensure optimal storage conditions, it is recommended to keep the product at a temperature of -20°C for up to a year. It is important to avoid subjecting the product to repeated freeze and thaw cycles, as this can lead to degradation and reduced effectiveness. It is therefore essential to handle the product with care and follow the recommended storage guidelines to ensure its quality and efficacy.
Storage bufferThis product is Rabbit IgG that has been formulated in phosphate buffered saline with a pH of 7.4. It also contains 150mM NaCl, 0.02% sodium azide and 50% glycerol. To ensure the product's stability, it is recommended that it be stored at a temperature of -20 °C. You can expect this product to remain stable for 12 months from the date it was received. Please ensure you read all manufacturer's instructions carefully before use.

Target

Background

The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist).

Tissue specificityExpressed primarily in the bone marrow and eosinophils. Shows preferential distribution in cells of immunological relevance such as T-cells, dendritic cells, monocytes, mast cells, neutrophils. Also expressed in a wide variety of peripheral tissues, including the heart, kidney, liver, lung, pancreas, skeletal muscle, prostate, small intestine, spleen, testis, colon, fetal liver and lymph node.
Celluar localizationPlasma Membrane;
UniPortQ9H3N8


Western blot analysis Histamine H4 Receptor using K562 whole cell lysates


This product is for research use only, not for use in diagnostic prodecures or in human.


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