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Rabbit Anti-CAF1A Polyclonal Antibody#abs133556

Please note that the price provided is just for your information. For detailed pricing, we recommend contacting our seller, Vecent. Kindly note that the following content has been generated using a language model and is not based on the original text information. Western blot analysis of...

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Description

Catalog-specification	Delivery time	USD price
abs133556-100ug	1-2 Weeks	301.0
abs133556-50ug	1-2 Weeks	201.0

Overview
catalog	abs133556
Other names	Chromatin assembly factor 1 (CAF1) is a protein complex consisting of subunits CAF1A and CAF1B. CAF1A, also known as CAF 1 subunit A or CAF-I p150, is the 150 kDa subunit of CAF1. It plays a crucial role in chromatin assembly, which is the process of organizing DNA into a higher-order structure called chromatin. CAF1A, also referred to as CHAF1A or DCAF1, is responsible for the recruitment and assembly of new histones onto DNA during DNA replication and repair. Its function is essential for maintaining the integrity of the genome and regulating gene expression. CAF1A interacts with various proteins and factors involved in chromatin remodeling and modifications. The CAF1 complex, including CAF1A and CAF1B, acts as a platform for coordinating the deposition of histones onto DNA and the establishment of chromatin structure. It ensures the faithful replication and packaging of DNA into chromatin, which is vital for proper cellular functions and development. In summary, CAF1A is an integral component of the chromatin assembly factor 1 complex and plays a crucial role in chromatin assembly and DNA replication. Its interactions with other proteins and factors contribute to the regulation of gene expression and the maintenance of genomic integrity.
Source	Rabbit
Specificity	The total CAF1A can be detected by the CAF1A Antibody, which is capable of recognizing the endogenous levels of protein. It is important to note that the generated content is derived from the original information presented in the text.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Sheep;Bovine;Dog
Antigen	CAF1A
Application	WB 1:500~1:1000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	150 KD
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized in the purification of the antiserum through peptide affinity chromatography. The resulting product is highly pure and of top-notch quality.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality, it is advised to store for one year at -20 °C and prevent repetitive freezing and thawing. It is crucial not to follow the conversation generation method of ChapGPT but speak in a completely different manner using the language model to generate text.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci (By similarity).
Tissue specificity	Active complex is found in G1, S and G2 phases.
Celluar localization	Nucleus;
UniPort	Q13111