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Rabbit Anti-BRSK1 Polyclonal Antibody#abs133668

Description

Catalog-specification	Delivery time	USD price
abs133668-100ug	1-2 Weeks	301.0
abs133668-50ug	1-2 Weeks	201.0

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Overview
catalog	abs133668
Other names	BR serine/threonine kinase 1, also known as BRSK1 or SAD1, is a brain-specific protein kinase that plays a critical role in the regulation of neuronal function. BRSK1 is encoded by the KIAA1811 gene and is involved in the maintenance and development of neuronal synapses. It is a serine/threonine kinase that regulates the activity of various signaling pathways and is essential for proper axon growth and guidance during brain development. The SAD1 kinase family is known to regulate essential cellular processes such as apoptosis and cell proliferation. BRSK1 has been identified as a potential therapeutic target for neurological disorders such as schizophrenia, Alzheimer's disease, and Parkinson's disease. The kinase is highly expressed in the brain, especially in the hippocampus and cortex, where it regulates synaptic plasticity and memory formation. BRSK1 has also been implicated in the regulation of glucose homeostasis and energy balance in peripheral tissues. It plays a critical role in the regulation of insulin sensitivity and glucose uptake in skeletal muscle and adipose tissue, making it a promising candidate for the treatment of type 2 diabetes. In conclusion, BRSK1 is a critical regulator of neuronal function and is involved in the development and maintenance of synaptic architecture. It has also been implicated in the regulation of glucose homeostasis and energy balance in peripheral tissues. Further studies are needed to uncover the full range of functions of this important kinase and its potential as a therapeutic target for neurological and metabolic disorders.
Source	Rabbit
Specificity	Total BRSK1 levels are detected by the BRSK1 Antibody, which specifically targets the endogenous expression of the protein.
Species Reactivity	Human;Mouse
Predictive reaction species	Pig;Sheep;Dog;Bovine;Horse
Antigen	BRSK1
Application	：WB1:500~1:1000，IF/ICC1:100-1:500，ELISA(peptide)1:20000-1:40000。。
Immunogen	A synthesized peptide.
MW	87 KD
Properties
Concentration	1mg/ml
purification	We used SulfoLink™ Coupling Resin for peptide affinity chromatography to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the integrity of the product, it is recommended to store it at a temperature of -20 °C for a period of one year. It is important to avoid subjecting it to repeated freeze/thaw cycles, as this could lead to degradation of the product's quality. Therefore, it is essential to handle the product carefully and follow the recommended storage instructions to ensure its effectiveness and longevity.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C.
Tissue specificity	Widely expressed, with highest levels in brain and testis. Protein levels remain constant throughout the cell cycle.
Posttranslational modification	Phosphorylated at Thr-189 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Not phosphorylated at Thr-189 by CaMKK2. In contrast, it is phosphorylated and activated by CaMKK1. May be inactivated via dephosphorylation of Thr-189 by PP2C.
Celluar localization	Cytoskeleton;Nucleus;
UniPort	Q8TDC3