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Rabbit Anti-BNIP3 Polyclonal Antibody#abs137665

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Description

Catalog-specification	Delivery time	USD price
abs137665-100ug	1-2 Weeks	301.0
abs137665-50ug	1-2 Weeks	201.0

Overview
catalog	abs137665
Other names	The BCL2 Adenovirus E1B 19kDa Interacting Protein 3, also known as BCL2/adenovirus E1B 19 kDa protein interacting protein 3 or BNIP3, is a protein that interacts with the BCL2/adenovirus E1B 19 kDa protein. It is also referred to as BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 or NIP3. This protein, coded by the BNIP3 gene in humans, plays an important role in various cellular functions. Its functions and interactions make it a vital component of cellular mechanisms.
Source	Rabbit
Specificity	The total BNIP3 levels in cells can be detected by the BNIP3 Antibody, which specifically targets the endogenous form of BNIP3. By rearranging the original content, a similar message is conveyed, emphasizing the ability of the antibody to detect total BNIP3 levels in cells.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Rabbit;Pig;Dog;Horse;Bovine
Antigen	BNIP3
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human BNIP3.
MW	30 kDa
Properties
Concentration	1mg/ml
purification	Purification of the antiserum was accomplished through peptide affinity chromatography, wherein SulfoLink™ Coupling Resin was utilized.
Clonality	Polyclonal Antibody
Stability & Storage	It is recommended to keep the product in a temperature of -20°C for a duration of one year. Please avoid exposing the substance to multiple freeze/thaw cycles as it may affect its quality.
Storage buffer	This solution contains Rabbit IgG dissolved in phosphate buffered saline (pH 7.4), supplemented with 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is recommended to store this solution at a temperature of -20 °C. Please note that this solution maintains its stability for a period of 12 months from the date of receipt.
Target
Background	Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway.
Celluar localization	Endoplasmic reticulum;Mitochondrion;Nucleus;
UniPort	Q12983