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Rabbit Anti-BIRC3 Polyclonal Antibody#abs137102

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Description

Catalog-specification	Delivery time	USD price
abs137102-100ug	1-2 Weeks	301.0
abs137102-50ug	1-2 Weeks	201.0

Overview
catalog	abs137102
Other names	AIP1, also known as apoptosis inhibitor 1, is a protein that plays an important role in the regulation of programmed cell death. Another protein involved in apoptosis regulation is API2, also called apoptosis inhibitor 2. Both AIP1 and API2 belong to the baculoviral IAP repeat-containing protein family, which also includes BIRC3 or baculoviral IAP repeat-containing protein 3. These proteins are involved in the inhibition of caspases, which are key enzymes involved in the apoptotic process. AIP1 and API2 also interact with TNF receptor-associated factors (TRAFs), which are involved in the signaling pathways of TNF receptors. In addition to their role in apoptosis regulation, AIP1 and API2 have also been implicated in cancer development and progression. They may contribute to tumor cell survival by inhibiting apoptosis. Overall, the study of AIP1, API2, and other proteins involved in apoptosis regulation is important for understanding the mechanisms of cell death and survival in both normal and pathological conditions.
Source	Rabbit
Specificity	The total BIRC3 levels can be detected using the BIRC3 Antibody, which specifically targets the endogenous levels of BIRC3 protein.
Species Reactivity	Human
Predictive reaction species	Sheep
Antigen	BIRC3
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human BIRC3.
MW	72 kDa
Properties
Concentration	1mg/ml
purification	We utilized SulfoLink™ Coupling Resin in the process of purifying the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the integrity of the product, it is recommended to keep it stored at a temperature of -20 °C for a period of one year. It is important to avoid exposing the product to repeated freeze and thaw cycles as this may affect its quality. Therefore, it is advised to handle the product with care during storage to ensure its longevity and efficacy.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.
Tissue specificity	Highly expressed in fetal lung, and kidney. In the adult, expression is mainly seen in lymphoid tissues, including spleen, thymus and peripheral blood lymphocytes.
Posttranslational modification	Auto-ubiquitinated and degraded by the proteasome in apoptotic cells.
Celluar localization	Cytosol;Nucleus;
UniPort	Q13489