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Rabbit Anti-APPBP2 Polyclonal Antibody#abs140850

Please note that the price provided above is for your reference only. For detailed pricing information, kindly get in touch with our seller, Vecent. Feel free to contact Vecent for more details. Western blot analysis of extracts from 293 cells, using APPBP2 antibody. This product is for research...

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Description

Catalog-specification	Delivery time	USD price
abs140850-100ug	1-2 Weeks	301.0
abs140850-50ug	1-2 Weeks	201.0

Please note that the price provided above is for your reference only. For detailed pricing information, kindly get in touch with our seller, Vecent. Feel free to contact Vecent for more details.

Overview
catalog	abs140850
Other names	Protein interacting with APP tail 1, also known as amyloid beta precursor protein-binding protein 2 or APP-BP2, is a key player in the regulation of amyloid beta precursor protein (APP) metabolism. This protein binds to the cytoplasmic tail of APP, a precursor protein to the beta-amyloid peptide that accumulates in the brains of Alzheimer's disease patients. By interacting with APP, APP-BP2 modulates the processing and degradation of APP in the cell. The protein has also been suggested to play a role in the regulation of other pathways related to cell growth and differentiation. Due to its involvement in the pathogenesis of Alzheimer's disease, APP-BP2 has emerged as a potential therapeutic target for the treatment of this devastating disorder.
Source	Rabbit
Specificity	The APPBP2 Antibody is capable of detecting the total endogenous levels of APPBP2 in a given sample. This means that the antibody can be used to measure the total quantity of APPBP2 present in a sample, without the need for additional assays or techniques. With this antibody, researchers can obtain accurate and reliable results when studying the role and functions of APPBP2 in various biological processes.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Zebrafish;Chicken;Rabbit;Xenopus;Dog;Horse;Bovine;Sheep;Pig
Antigen	APPBP2
Application	For Western blotting, the recommended dilution range is 1:500 to 1:1000. For immunofluorescence and immunocytochemistry, a dilution of 1:100 to 1:500 is suggested. When using ELISA with peptide samples, it is recommended to dilute the sample at a range of 1:20000 to 1:40000. Please note that these dilution ranges are provided as a guideline and may require optimization for individual experimental conditions.
Immunogen	A synthesized peptide.
MW	67 KD
Properties
Concentration	1mg/ml
purification	By utilizing SulfoLink™ Coupling Resin, peptide affinity chromatography was employed to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure optimal storage conditions, it is recommended that the product be kept at a temperature of -20 °C for a period of one year. It is important to note that repeated cycles of freezing and thawing should be avoided to prevent damage to the product. Take care to follow these storage instructions carefully to maintain the quality and integrity of the product.
Storage buffer	The Rabbit IgG is accompanied by a convenient storage solution, consisting of phosphate buffered saline at pH 7.4, with 150mM NaCl, 0.02% sodium azide, and 50% glycerol. For optimal preservation, it is recommended that the product be stored at a temperature of -20 °C. The solution remains stable for a duration of 12 months from the date of receipt, ensuring a reliable and robust storage solution for this important compound.
Target
Background	May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface.
Posttranslational modification	Rapidly degraded by the proteasome upon overexpression of a C-terminal fragment of APP.
Celluar localization	Cytoskeleton;Nucleus;
UniPort	Q92624