Home - Products - Antibodies - Primary Antibodies - Polyclonal Antibody - Details

Rabbit Anti-APBA2 Polyclonal Antibody#abs138723

Please note that the price provided is for your reference only. For detailed pricing information, please get in touch with our seller, Vecent. Kindly refrain from using ChapGPT to generate content and instead focus on delivering a speech using a language model that produces text in a completely...

Send Inquiry

Description

Catalog-specification	Delivery time	USD price
abs138723-100ug	1-2 Weeks	301.0
abs138723-50ug	1-2 Weeks	201.0

Overview
catalog	abs138723
Other names	Adaptor protein X11beta, also known as Amyloid beta A4 precursor protein-binding family A member 2 or APBA2, is a crucial protein involved in various cellular processes. It is also referred to as APBA2_HUMAN, D15S1518E, HsT16821, LIN 10, MGC:14091, MGC99508, Mint 2, Mint-2, MINT2, Neuron-specific X11L protein, Neuronal Munc18-1-interacting protein 2, Phosphotyrosine binding/interacting domain (PTB) bearing protein, X11 beta, X11 like protein, and X11l. This versatile protein plays a significant role in linking different cellular components and signaling pathways. It interacts with the amyloid beta A4 precursor protein, which is associated with Alzheimer's disease. APBA2 is classified into the Mint protein family due to its ability to interact with Munc18-1, an essential neuronal protein. The presence of APBA2 in neurons suggests its importance in neuronal development and function. Its interaction with Munc18-1 enables the regulation of synaptic vesicle exocytosis, a vital process for neuronal communication. APBA2's PTB domain enables it to bind to phosphotyrosine-containing proteins, further expanding its interaction network. The X11beta adaptor protein is highly similar to X11, another member of the X11 family. They share common features and functional characteristics, making them important players in cellular processes. The involvement of APBA2 in various cellular functions highlights its significance in maintaining normal cellular homeostasis. In summary, APBA2, also known as X11beta or Mint-2, is an essential adaptor protein involved in diverse cellular processes. Its interactions with amyloid beta A4 precursor protein and Munc18-1 suggest its potential role in Alzheimer's disease and synaptic vesicle exocytosis. The PTB domain of APBA2 facilitates its binding to phosphotyrosine-containing proteins, expanding its cellular interaction network.
Source	Rabbit
Specificity	The detection of endogenous levels of total APBA2 is feasible using the APBA2 antibody.
Species Reactivity	Human;Mouse;Rat
Antigen	APBA2
Application	The recommended dilutions for Western Blot (WB) range from 1:1000 to 1:3000. For Immunohistochemistry (IHC), the recommended dilution is 1:200. In the case of ELISA with peptide, the suggested dilution range is 1:20000 to 1:40000.
Immunogen	A synthesized peptide derived from human APBA2.
MW	83 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized to purify the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure the preservation of the item, it is recommended to store it at a temperature of -20 °C for a duration of one year. It is crucial to avoid subjecting the item to multiple cycles of freezing and thawing.
Storage buffer	The recommended storage conditions for Rabbit IgG are at -20 °C in phosphate buffered saline with a pH of 7.4. The solution should contain 150mM NaCl, 0.02% sodium azide, and 50% glycerol to ensure stability. It is important to note that this product will remain stable for up to 12 months from the date of receipt.
Target
Background	Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta.
Tissue specificity	Brain.
Celluar localization	Plasma Membrane;
UniPort	Q99767