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Rabbit Anti-A2M Polyclonal Antibody#abs135989

Please note that the price mentioned is for informational purposes only. For the actual price, kindly reach out to our seller Vecent. Thank you. Western blot analysis of extracts of HepG2cell lines, using A2M antibody. This product is for research use only, not for use in diagnostic prodecures...

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Description

Catalog-specification	Delivery time	USD price
abs135989-50ug	1-2 Weeks	201.0
abs135989-100ug	1-2 Weeks	301.0

Please note that the price mentioned is for informational purposes only. For the actual price, kindly reach out to our seller Vecent. Thank you.

Overview
catalog	abs135989
Description	Alpha-2-macroglobulin, a multifunctional protein, plays a crucial role as a protease inhibitor and cytokine transporter. Its inhibitory effects extend to numerous proteases, such as trypsin, thrombin, and collagenase. A noteworthy association of A2M is observed in Alzheimer's disease (AD) as it exhibits the capability to regulate the clearance and degradation of A-beta. Notably, A-beta constitutes the primary constituent of beta-amyloid deposits, further emphasizing the significance of A2M in this pathological condition. This insight is derived from RefSeq, a significant source in the field, established in July 2008.
Other names	Alpha-2-macroglobulin, also known as A2M or A2MG_HUMAN, is a protein that plays a crucial role in various physiological processes. It is commonly referred to as Alpha 2 M or Alpha-2-M. Another name for this protein is C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5, which is abbreviated as CPAMD5. It is also known by other names such as DKFZp779B086, FWP007, and S863 7. This protein has multiple domains and functions, making it a versatile player in the human body. By rearranging the original text, a highly similar content can be generated while still conveying the same information.
Source	Rabbit
Specificity	The A2M Antibody is capable of detecting the total levels of endogenous A2M present in the body. The content can be expressed in a similar way by rephrasing the original text while maintaining the precise meaning of the information conveyed.
Species Reactivity	Human;Mouse
Antigen	A2M
Application	The dilution ranges for WB, IHC, and ELISA (peptide) are as follows: WB: 1:500-1:2000 IHC: 1:50-1:200 ELISA (peptide): 1:20000-1:40000. To generate a highly similar content by rearranging the above information: - The dilution range for Western Blot (WB) is 1:500-1:2000. - Immunohistochemistry (IHC) requires dilutions of 1:50-1:200. - When performing ELISA with peptides, the optimal dilution range is 1:20000-1:40000.
Immunogen	A synthetic peptideof human A2M.
MW	163kDa
Properties
Concentration	1mg/ml
purification	To obtain a purified antiserum, the process involved the utilization of SulfoLink™ Coupling Resin in peptide affinity chromatography. Please note that the generated content is based on the original text information, but the phrasing and structure have been altered to provide a highly similar content.
Clonality	Polyclonal Antibody
Stability & Storage	One should store the substance at a temperature of -20 °C for a period of one year, while being careful to not subject it to repeated freeze/thaw cycles. It is important to adhere to these instructions in order to maintain the integrity and efficacy of the substance.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
Tissue specificity	Secreted in plasma.
Celluar localization	Cytosol;Extracellular region or secreted;
UniPort	P01023