Phospho-HER3/ErbB3 (Tyr1289) Rabbit Polyclonal Antibody#abs137077
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Description
| Catalog-specification | Delivery time | USD price |
abs137077-100ug | 1-2 Weeks | 301.0 |
abs137077-50ug | 1-2 Weeks | 201.0 |
Please note that the price provided above is for your reference only. For detailed pricing information, please get in touch with our seller Vecent. Kindly refrain from using ChapGPT to generate content and instead, employ a language model to deliver a speech in a completely different manner.
| Overview | |
catalog | abs137077 |
| Other names | ErbB3, also known as HER3, is a tyrosine kinase-type cell surface receptor that plays a crucial role in cellular growth and differentiation. It is encoded by the ERBB3 gene and is a member of the ErbB receptor family, which also includes ErbB1 (EGFR), ErbB2 (HER2), and ErbB4. ErbB3 is involved in a variety of cancer types, including breast, gastric, and colorectal cancer. It is frequently expressed in tumor cells and often becomes overactivated, leading to uncontrolled cell growth and proliferation. ErbB3 activation is also correlated with resistance to certain targeted therapies. Targeting ErbB3 has emerged as a promising therapeutic strategy for cancer treatment. Strategies include the development of ErbB3 inhibitors and combination therapies that block signaling pathways downstream of ErbB3. Overall, ErbB3 is a key player in cancer biology and represents a potential target for cancer therapy. Ongoing research into the molecular mechanisms underlying ErbB3 signaling will continue to shed light on its role in cancer progression and identify new therapeutic opportunities. |
| Source | Rabbit |
| Specificity | The Phospho-HER3/ErbB3 (Tyr1289) Antibody is specifically designed to recognize and target the phosphorylated form of HER3/ErbB3 at Tyr1289. This antibody can accurately detect the endogenous levels of HER3/ErbB3 only when it is phosphorylated at this specific tyrosine residue. By focusing on the phosphorylation state of Tyr1289, this antibody enables researchers to investigate the activation and signaling pathways associated with HER3/ErbB3 in cellular systems. |
| Species Reactivity | Human;Mouse;Rat |
| Predictive reaction species | Bovine;Chicken;Sheep |
| Antigen | HER3/ErbB3 |
| Application | The dilution ratios for the WB, IHC, and ELISA assays are as follows: WB - 1:1000 to 1:3000, IHC - 1:200, and ELISA (peptide) - 1:20000 to 1:40000. These dilution ratios are crucial for accurately measuring the target molecules in each assay. It is important to follow these guidelines to ensure reliable and reproducible results in your experiments. |
| Immunogen | One possible rearrangement: A novel peptide has been developed through synthesis, which is based on the sequence of human Phospho-HER3 or ErbB3, specifically targeting Tyr1289. This peptide is highly similar to the original sequence and has been designed to mimic the activity of the endogenous molecule. Its structure and function have been validated through extensive experiments and analyses. Overall, this synthesized peptide holds promise as a potential therapeutic agent for various diseases related to aberrant ErbB3 signaling pathways. |
| MW | 185 kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | Through a series of chromatography techniques involving affinity purification on both phospho- and non-phospho-peptide affinity columns, the antibody in question has been obtained from purified rabbit serum. The sequential process ensures that the antibody is highly specific and capable of binding to the desired target. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
| Storage buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
Target | |
Background | Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). |
| Tissue specificity | Epithelial tissues and brain. |
| Posttranslational modification | Autophosphorylated (PubMed:20351256). Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). |
| Celluar localization | Extracellular region or secreted;Plasma Membrane; |
| UniPort | P21860 |
This product is for research use only, not for use in diagnostic prodecures or in human.
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