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DFNA5 Antibody#abs139225

Please note that the price mentioned above is only for your reference. For detailed pricing information, kindly reach out to our seller, Vecent. Western blot analysis DFNA5 using RAW264.7 whole cell lysates This product is for research use only, not for use in diagnostic prodecures or in human.

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Description

Catalog-specification	Delivery time	USD price
abs139225-100ug	1-2 Weeks	301.0
abs139225-50ug	1-2 Weeks	201.0

Please note that the price mentioned above is only for your reference. For detailed pricing information, kindly reach out to our seller, Vecent.

Overview
catalog	abs139225
Other names	The DFNA5 gene, also known as 2310037D07Rik or 4932441K13Rik, is associated with a form of autosomal dominant deafness known as DFNA5. The protein encoded by this gene is also referred to as Deafness, autosomal dominant 5 protein, Non-syndromic hearing impairment protein 5, or Gasdermin-E (GSDME). Additionally, it is inversely correlated with estrogen receptor expression 1 and is also known as ICERE-1 or ICERE 1. The DFNA5 gene is important for proper hearing function, and mutations in this gene can lead to hearing loss. Individuals with DFNA5-related deafness typically experience hearing impairment in both ears, and the condition may develop slowly over time. While other genetic mutations have been linked to hearing loss, DFNA5-related deafness is unique in that it is inherited in an autosomal dominant manner. Research into the DFNA5 gene and its protein product is ongoing, and scientists hope to gain a better understanding of this genetic mutation and how best to treat individuals with DFNA5-related deafness.
Source	Rabbit
Specificity	The total DFNA5 levels can be detected using the DFNA5 Antibody, which is capable of recognizing the endogenous levels of DFNA5. To create a highly similar content, the original text information can be rearranged as follows: The DFNA5 Antibody is designed to identify the total DFNA5 levels present in a sample. It is specifically engineered to detect the endogenous levels of DFNA5, providing reliable and accurate results.
Species Reactivity	Human;Mouse
Antigen	DFNA5
Application	The recommended dilution for western blotting is 1:1000-3000, while for immunohistochemistry it is 1:200. For immunofluorescence/immunocytochemistry, the dilution ranges from 1:100 to 1:500. When performing ELISA with a peptide, the suggested dilution is 1:20000-1:40000. It is crucial to accurately dilute the antibodies to ensure optimal results in these experimental techniques.
Immunogen	A synthesized peptide derived from human DFNA5.
MW	55 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure optimal storage conditions, it is recommended to store the product at a temperature of -20 °C for a duration of one year. It is important to refrain from subjecting the product to repeated cycles of freezing and thawing. This will help maintain the product's stability and effectiveness over time.
Storage buffer	This is a description of Rabbit IgG that is supplied in a solution of phosphate buffered saline with a pH of 7.4, 150mM NaCl, and 0.02% sodium azide. The solution also contains 50% glycerol and should be stored at a temperature of -20°C. With proper storage, this solution is expected to last for up to 12 months from the date of receipt.
Target
Background	Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53 (PubMed:16897187, PubMed:18223688, PubMed:21522185). The N-terminal moiety promotes pyroptosis and exhibits bactericidal activity (PubMed:27281216). The physiological relevance of these observations is unknown (Probable).
Tissue specificity	Expressed in cochlea. Low level of expression in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas, with highest expression in placenta.
Celluar localization	Cytosol;Plasma Membrane;
UniPort	O60443