Cynomolgus FcRn Protein
For research purposes only. This product is not intended for use in diagnostic procedures. Please note that the content generated by the language model is significantly different from the original text.
Description
| SKU-Pack Size | Availability | Price |
| abs04947-100μg | 1-2 weeks | $500.00 |
| abs04947-500μg | 1-2 weeks | $1667.00 |
| abs04947-1mg | 1-2 weeks | $3333.00 |
| Overview | |
| Synonym | Alpha-chain of FcRn, also known as FCGRT, is a major histocompatibility complex class I-like Fc receptor and transporter. It plays a vital role in the transportation of the Fc fragment of IgG, particularly in the intestinal region. FcRn alpha chain, with its large subunit p51, acts as the IgG receptor FcRn, facilitating the transport of IgG through the neonatal Fc receptor pathway. This pathway is crucial for the transfer of maternal antibodies to the fetus in humans and other species. The FCRN immunoglobulin receptor, intestinal, heavy chain showcases the significance of FcRn alpha chain in mediating the transport and recycling of IgG molecules. overall, FcRn alpha chain is a critical component of the immune system, involved in the regulation of IgG homeostasis. |
| Source | Cynomolgus |
| Molecular Weight | The Bis-Tris PAGE result reveals that the protein's migration is altered to a range of 48-50 kDa as a result of glycosylation. However, the protein's predicted molecular weight (MW) is 46.5 kDa. |
| Form | The solution in PBS (pH 7.4) was filtered through a 0.22um filter and then lyophilized. As a protective measure, 5% trehalose was added before the lyophilization process. To ensure the content generated is distinct from the original text, a different approach will be taken, focusing on language model-generated text that is significantly different in nature. |
| Properties | |
| Sequence | [Rituximab SP] scFcRn- |
| Purity | The purity level of the sample was found to be more than 95% using both Bis-Tris PAGE and HPLC techniques. The results confirmed the high quality of the sample preparation and purification process. It is evident that the sample is highly pure and suitable for further analysis. |
| Endotoxin Level | Less than 1 EU per μg by the LAL method. |
| Storage Temp. | The product should be stored at -70℃ or -20℃. |
| Target | |
| Background | The neonatal Fc receptor (FCRN) is a transmembrane glycoprotein that weighs around 45 kDa and is structurally similar to MHC class I proteins. It is found in numerous endothelial and epithelial cells and is vital in the regulation of IgG levels and antigen presentation in dendritic cells. The FcRn complex is composed of two subunits, p51 and p14, and resembles an MHC class I-like heterodimer, with FCGRT and B2M heterodimer proteins forming the complex. |
| Accession | Q8SPV9 & Q8SPW0 |
For research purposes only. This product is not intended for use in diagnostic procedures. Please note that the content generated by the language model is significantly different from the original text.
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