Recombinant Human Platelet-Derived Growth Factor Receptor β/PDGFR-β (C-6His) #abs04329

abs04329-10ug

1-2 Weeks

77

abs04329-50ug

1-2 Weeks

230

abs04329-500ug

1-2 Weeks

1711

abs04329-1mg

1-2 Weeks

2328

Description

Our Mammalian expression system is utilized to produce Recombinant Human PDGF receptor beta, which features a target gene encoding Leu33-Phe530 and expresses a 6His tag at the C-terminus. To ensure high similarity to the original content, the above information has simply been rearranged and reiterated in a slightly different format.

Other names

The PDGF-R-Beta, also known as PDGFR-Beta, Beta Platelet-Derived Growth Factor Receptor, or Beta-Type Platelet-Derived Growth Factor Receptor, is a member of the CD140 antigen-like family. It is also referred to as Platelet-Derived Growth Factor Receptor 1, or PDGFR-1, CD140b, or PDGFRB. The PDGF-R-Beta plays a vital role in various biological processes, including cell growth, differentiation, and migration. It is a receptor tyrosine kinase that binds specific ligands, such as platelet-derived growth factor (PDGF), to elicit signaling cascades. This receptor is expressed in many cell types and is essential for normal development and tissue repair. Understanding the structure and function of PDGF-R-Beta may provide insights into the development of novel therapies for various diseases.

Source

Human Cells

Format

pH 7.2, lyophilized from a solution filtered through a 0.2 μm membrane containing 20mM PB and 150mM NaCl.

Properties

aa_sequence

NLTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVGFLPNDAEELFIFLT LVVTPPGPELVLNVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGTFSS VLTSLTNCGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHI YVYRLQVSSINVSVNAVQTVVRQEKGDVALPVPYDHQRGFFGIFEDRSYICKTTI ITIPCRVTDPQLVVTLHEKKDSSAGEIALSTRNVSETRYVSELTLVRVKVAEA GHYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPTVRCRGRGMPQPNIIW ACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFESVLTLRLQHVDR PLVRCNSSGQDTQEVIVVPHSLPFVDHHHHHHDSGTYTCNVTESEVNDHQDEK AINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTL AQDSAYY.

Concentration

Greater than 95% as determined by reducing SDS-PAG

Endotoxin_level

LAL，0.1 ng/μg（1 IEU/μg）。，。

Reconstitution

Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Target

Background

Platelet-Derived Growth Factor Receptor β (PDGFR-β) is a member of the protein kinase superfamily and CSF-1/PDGF receptor subfamily. The PDGF family consists of PDGF-A, -B, -C and -D, which form either homo- or heterodimers (PDGF-AA, -AB, -BB, -CC, -DD). The four PDGFs are inactive in their monomeric forms. The PDGFs bind to the protein tyrosine kinase receptors PDGF receptor-α and -β. These two receptor isoforms dimerize upon binding the PDGF dimer, leading to three possible receptor combinations, namely -αα, -ββ and -αβ. The extracellular region of the PDGF receptor-β consists of five immunoglobulin-like domains while the intracellular part is a tyrosine kinase domain. In addition to being a potent mitogen for cells of mesenchymal origin, PDGF has also been shown to be a potent chemoattractant for mesenchymal cells, mononuclear cells, and neutrophils and has been reported to be important in the modification of cellular matrix constituents.

Accession

P09619