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Rabbit Anti-XCR1 Polyclonal Antibody#abs138566

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Description

Catalog-specification	Delivery time	USD price
abs138566-100ug	1-2 Weeks	301.0
abs138566-50ug	1-2 Weeks	201.0

Overview
catalog	abs138566
Other names	XCR1, also known as CCXCR 1, G protein coupled receptor 5, lymphotactin receptor, and XC chemokine receptor 1, is a chemokine receptor that plays a crucial role in the immune system. It is a member of the G protein-coupled receptor family and is involved in the binding and activation of chemokines. As its name suggests, XCR1 specifically binds to chemokines belonging to the XC family. These chemokines are produced by activated CD8+ T cells and dendritic cells and are involved in the regulation of immune responses, inflammation, and cancer. The XCR1 receptor is mainly expressed on dendritic cells and some subsets of T cells, where it helps to mediate the recruitment and activation of immune cells in response to chemokine signaling. XCR1 signaling has been shown to play a role in various immune-related processes such as antigen presentation, T cell activation, and regulation of immune tolerance. Moreover, the XCR1 receptor has been implicated in the pathogenesis of several diseases, including cancer and inflammatory disorders, making it a potential therapeutic target. Harnessing XCR1 signaling may pave the way for the development of novel immunotherapeutic approaches for the treatment of these diseases.
Source	Rabbit
Specificity	The XCR1 Antibody is capable of detecting the complete amount of XCR1 present in the system, including its endogenous levels. To create a similar content in a rearranged manner, the statement can be expressed as follows: Detection of total XCR1 including its endogenous levels can be accomplished with the utilization of XCR1 Antibody.
Species Reactivity	Human
Antigen	XCR1
Application	The recommended dilution for Western blotting is between 1:1000 to 1:3000. For immunohistochemistry, dilution should be kept at 1:200, while for ELISA-based testing with a peptide substrate, dilution should be between 1:20000 to 1:40000. It is important to keep dilutions accurate to ensure reliable and reproducible results.
Immunogen	A synthesized peptide derived from human XCR1.
MW	39 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification via peptide affinity chromatography. To obtain a highly purified antiserum, the resin was utilized for its affinity to specific peptides. Through this process, the antiserum was isolated and separated from other impurities.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the integrity of the product, it is recommended to store it at a temperature of -20 °C for a period of one year. It is crucial to prevent the occurrence of repeated freeze/thaw cycles. It is highly advised to follow these storage instructions diligently.
Storage buffer	To maintain the stability of the rabbit IgG, it is stored in a phosphate buffered saline solution with a pH of 7.4, 150mM NaCl, and 0.02% sodium azide. Additionally, the solution is mixed with 50% glycerol and stored at -20°C, allowing for a longer shelf life of up to 12 months from the date of receipt. It is important to preserve the integrity of the product by following proper storage instructions to ensure that it can effectively carry out its intended purpose.
Target
Background	Receptor for chemokines SCYC1 and SCYC2. Subsequently transduces a signal by increasing the intracellular calcium ions level. Receptor for XCL1/Lymphotactin.
Celluar localization	Plasma Membrane;
UniPort	P46094