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Rabbit Anti-TYROBP Polyclonal Antibody#abs136828

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Description

Catalog-specification	Delivery time	USD price
abs136828-100ug	1-2 Weeks	301.0
abs136828-50ug	1-2 Weeks	201.0

Overview
catalog	abs136828
Description	This particular gene codes for a polypeptide involved in signaling across cell membranes. It possesses a cytoplasmic domain that contains an immunoreceptor tyrosine-based activation motif (ITAM). This protein has the potential to interact with the killer-cell inhibitory receptor (KIR) family of glycoproteins on the cell membrane, potentially functioning as a trigger for signal transduction. It is capable of binding to zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK), playing a vital role in signal transduction, bone development, brain myelination, and inflammation. Mutations in this gene have been linked to a specific disorder called polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), or Nasu-Hakola disease. Interestingly, the putative receptor of this gene, known as triggering receptor expressed on myeloid cells 2 (TREM2), is also associated with PLOSL. Various alternative forms of transcripts, producing distinct isoforms, have been identified for this gene. Please note that this generated content has been rearranged, but the information remains consistent with the original text.
Other names	TYROBP, also known as DAP12 or DNAX activation protein 12, is a protein that plays a crucial role in immune system function. It is also referred to as KAR-associated protein or Killer activating receptor associated protein, reflecting its association with killer activating receptors involved in the immune response. TYROBP is a TYRO protein tyrosine kinase binding protein, which means it binds to proteins involved in signal transduction pathways crucial for immune cell activation. It is an adaptor protein that facilitates signal transduction from cell surface receptors to intracellular signaling molecules. Mutations in the TYROBP gene have been linked to a rare neurological disorder called PLOSL, which stands for polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy. This disorder is characterized by bone cysts, progressive cognitive and motor dysfunction, and eventual paralysis. Overall, TYROBP is an important protein in the immune system and understanding its function may lead to novel therapeutic approaches for immune-related disorders.
Source	Rabbit
Specificity	The detection of total TYROBP can be achieved with the TYROBP Antibody, which effectively identifies the naturally occurring levels of TYROBP.
Species Reactivity	Human
Predictive reaction species	Rabbit;Pig;Dog;Horse;
Antigen	TYROBP
Application	The recommended dilutions for Western blot are 1:500 to 1:2000, for immunohistochemistry are 1:50 to 1:200, and for ELISA using peptide are 1:20000 to 1:40000. These guidelines are crucial to ensure accurate and reliable results, and should be followed closely to achieve optimal outcomes. Proper dilution of primary antibodies is critical for effective detection of target proteins in these assays. Therefore, it is important to carefully adjust the dilution ratios to fit the specific experiment's needs. By optimizing the dilutions and following recommended guidelines, researchers can obtain consistent and trustworthy data for their research.
Immunogen	A synthesized peptide derived from human TYROBP.
MW	12kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin.
Tissue specificity	Expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes. Expressed in hematological cells and tissues such as peripheral blood leukocytes and spleen. Also found in bone marrow, lymph nodes, placenta, lung and liver. Expressed at lower levels in different parts of the brain especially in the basal ganglia and corpus callosum.
Posttranslational modification	Tyrosine phosphorylated.
Celluar localization	Plasma Membrane;
UniPort	O43914