Rabbit Anti-TGF Beta Receptor III Polyclonal Antibody#abs138269
Please be advised that the price provided is for your reference only. For detailed pricing information, we kindly request you to get in touch with our seller, Vecent. Feel free to contact Vecent to obtain accurate and up-to-date pricing details. Western blot analysis TGF β Receptor III using...
Description
| Catalog-specification | Delivery time | USD price |
abs138269-100ug | 1-2 Weeks | 301.0 |
abs138269-50ug | 1-2 Weeks | 201.0 |
Please be advised that the price provided is for your reference only. For detailed pricing information, we kindly request you to get in touch with our seller, Vecent. Feel free to contact Vecent to obtain accurate and up-to-date pricing details.
| Overview | |
catalog | abs138269 |
| Other names | Betaglycan, also known as beta glycan or BGCAN, is a proteoglycan that plays a vital role in mediating cellular responses to transforming growth factor beta (TGF-beta) signaling. TGF-beta receptor type 3 (TGFB R3), also known as TGF-beta receptor type III or TGFR-3, is the protein that mediates the binding of TGF-beta to betaglycan. Together, they form the transform growth factor beta receptor III betaglycan 300kDa complex, which allows for the proper activation of downstream signaling pathways in response to TGF-beta stimulation. As a type III TGF-beta receptor, betaglycan is expressed in a wide variety of cell types and is known to regulate many physiological processes, including cell growth, differentiation, and apoptosis. Dysregulation of TGF-beta signaling has been implicated in the development and progression of many diseases, including cancer, fibrosis, and cardiovascular disease. Therefore, understanding the role of betaglycan and TGFB R3 in TGF-beta signaling is of great interest in the field of biomedical research. In summary, betaglycan is a proteoglycan that acts as a coreceptor for TGF-beta signaling, and TGFB R3 is the protein that mediates the binding of TGF-beta to betaglycan. Together, they play a critical role in mediating cellular responses to TGF-beta stimulation and regulating various physiological processes. |
| Source | Rabbit |
| Specificity | The antibody against TGF β Receptor III recognizes total endogenous levels of the protein. |
| Species Reactivity | Human;Mouse;Rat |
| Antigen | TGF β Receptor III |
| Application | WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000 |
| Immunogen | TGF β Receptor III is the source from which a synthesized peptide, specifically designed for human use, has been derived. The process involves rearranging the original content to create a highly similar version, while maintaining the factual information of the original text. |
| MW | 93 kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. A highly effective method for separating out specific components, this process ensures the highest level of purity for the resulting product. With this approach, the resulting antiserum is of the utmost quality and can be relied upon for a wide range of research and medical applications. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | To maintain the quality and stability of the product, it is recommended to keep it in a freezer at a temperature of -20 °C for a period of one year. It is important to avoid any instances of freezing and thawing cycles, as this may negatively impact the product's effectiveness. To ensure the product remains viable, it is recommended to adhere to the storage instructions as outlined. |
| Storage buffer | The storage condition for Rabbit IgG is -20 °C in phosphate buffered saline, pH 7.4, supplemented with 150mM NaCl, 0.02% sodium azide and 50% glycerol. It is important to note that this antibody is stable for a period of 12 months from the date of receipt. |
Target | |
Background | Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors. |
| Posttranslational modification | Extensively modified by glycosaminoglycan groups (GAG). |
| Celluar localization | Extracellular region or secreted;Plasma Membrane; |
| UniPort | Q03167 |
Western blot analysis TGF β Receptor III using HepG2 whole cell lysates
This product is for research use only, not for use in diagnostic prodecures or in human.
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