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Rabbit Anti-TF3C4 Polyclonal Antibody#abs138249

Please note that the price mentioned above is just for your reference. For detailed pricing information, we kindly ask you to get in touch with Vecent, our dedicated seller. Western blot analysis TF3C4 using A549 whole cell lysates This product is for research use only, not for use in diagnostic...

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Description

Catalog-specification	Delivery time	USD price
abs138249-100ug	1-2 Weeks	301.0
abs138249-50ug	1-2 Weeks	201.0

Please note that the price mentioned above is just for your reference. For detailed pricing information, we kindly ask you to get in touch with Vecent, our dedicated seller.

Overview
catalog	abs138249
Other names	KAT12, also known as General transcription factor 3C 4 or TFIIIC 90 kDa subunit, is an enzyme encoded by the gene FLJ21002. It is a crucial component of the transcription factor IIIC complex, responsible for the initiation of gene transcription. The protein plays a vital role in the regulation of gene expression and is involved in various cellular processes. One of the key functions of KAT12 is its involvement in the assembly of the transcription initiation complex. It interacts with other subunits of the TFIIIC complex to facilitate the binding of RNA polymerase and promote the efficient transcription of genes. This complex is essential for the accurate and controlled expression of genes in the cell. In addition to its role in transcription initiation, KAT12 has been implicated in chromatin remodeling and DNA repair processes. It can interact with other proteins involved in these pathways to regulate gene expression and maintain genomic stability. The gene FLJ21002, which encodes KAT12, is expressed in various tissues and is highly conserved across different species. Mutations in this gene have been associated with certain genetic disorders and diseases, highlighting the importance of KAT12 in normal cellular function. In conclusion, KAT12, also known as General transcription factor 3C 4 or TFIIIC 90 kDa subunit, is a crucial component of the transcription factor IIIC complex. It plays a vital role in transcription initiation, chromatin remodeling, and DNA repair processes, ensuring proper gene expression and genomic stability.
Source	Rabbit
Specificity	The endogenous levels of total TF3C4 can be detected using the TF3C4 Antibody.
Species Reactivity	Human;Mouse
Predictive reaction species	Rabbit;Pig;Dog;Horse;
Antigen	TF3C4
Application	The recommended dilution for Western blotting is between 1:1000 to 1:3000, while for IF/ICC it is between 1:100 to 1:500. When using ELISA with a peptide substrate, it is advisable to dilute the sample at a ratio of 1:20000 to 1:40000. To ensure accurate results, it is important to follow the recommended dilutions based on the original text information. By doing so, you can improve the accuracy and reliability of your experiments and obtain meaningful data.
Immunogen	A synthesized peptide derived from human TF3C4.
MW	92 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. The resulting product was highly purified and suitable for further experimentation.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality, store at a temperature of -20 °C for a duration of one year. It is crucial to prevent the occurrence of multiple freeze/thaw cycles.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be localized close to the A box.
Celluar localization	Mitochondrion;Nucleus;
UniPort	Q9UKN8