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Rabbit Anti-SMC3 Polyclonal Antibody#abs137039

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Description

Catalog-specification	Delivery time	USD price
abs137039-100ug	1-2 Weeks	301.0
abs137039-50ug	1-2 Weeks	201.0

Overview
catalog	abs137039
Other names	BAM; Bamacan; Basement membrane-associated chondroitin proteoglycan; Basement membrane-associated chondroitin proteoglycan; BMH; CDLS3; chondroitin sulfate proteoglycan 6 (bamacan); Chondroitin sulfate proteoglycan 6; Chromosome-associated polypeptide; Chromosome-associated polypeptide; CSPG 6; CSPG6; hCAP; Human chromosome-associated polypeptide; im:7142991; SMC 3; SMC protein 3; SMC-3; smc3; SMC3_HUMAN; SMC3L1; Structural maintenance of chromosome 3; Structural maintenance of chromosomes 3; Structural maintenance of chromosomes protein 3; u:fb22e01; wu:fc30d07; Here are some rearranged phrases using the original text information: 1. Chondroitin sulfate proteoglycan 6, also known as bamacan, is associated with the basement membrane and plays a role in maintaining the structure of chromosomes. 2. The chromosome-associated polypeptide, known as hCAP, is encoded by the SMC3 gene. 3. Basement membrane-associated chondroitin proteoglycan, or BAM, is a critical component involved in chromosome organization and structural maintenance. 4. CDLS3, or chromosome-associated polypeptide, is responsible for the proper functioning of chromosome 3. 5. SMC protein 3, also known as SMC3, is involved in the structural maintenance of chromosomes and is encoded by the SMC3L1 gene. It is important to note that the rearranged phrases may result in slight differences in wording but convey the same overall information as the original text.
Source	Rabbit
Specificity	The total SMC3 endogenous levels are detected by the SMC3 Antibody. Consider rearranging the content to maintain a similar meaning while presenting it in a different structure: "Endogenous levels of total SMC3 can be effectively detected using the SMC3 Antibody."
Species Reactivity	Human;Mouse
Antigen	SMC3
Application	For Western Blot analysis, a dilution of 1:1000-3000 is recommended. When performing Immunohistochemistry, a dilution of 1:200 will yield optimal results. Finally, for ELISA testing using a peptide antigen, a dilution range of 1:20000-1:40000 is suggested for best outcomes. It's essential to follow these specific dilutions to ensure accurate and reproducible results.
Immunogen	A synthesized peptide derived from human SMC3.
MW	142kDa
Properties
Concentration	1mg/ml
purification	The SulfoLink™ Coupling Resin was utilized in the purification process of the antiserum. The method employed was peptide affinity chromatography to ensure the isolation of the desired substance.
Clonality	Polyclonal Antibody
Stability & Storage	For optimal preservation, it is recommended to keep the product at a temperature of -20 °C for a period of one year. It is important to avoid subjecting the product to repeated freeze/thaw cycles as this can compromise its quality and potency.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement.
Posttranslational modification	Phosphorylated at Ser-1083 in a SPO11-dependent manner.Acetylation at Lys-105 and Lys-106 by ESCO1 is important for genome stability and S phase sister chromatid cohesion. Regulated by DSCC1, it is required for processive DNA synthesis, coupling sister chromatid cohesion establishment during S phase to DNA replication. Deacetylation by HDAC8, regulates release of the cohesin complex from chromatin.
Celluar localization	Cytoskeleton;Cytosol;Extracellular region or secreted;Nucleus;
UniPort	Q9UQE7