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Rabbit Anti-SELE Polyclonal Antibody#abs136434

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Description

Catalog-specification	Delivery time	USD price
abs136434-100ug	1-2 Weeks	301.0
abs136434-50ug	1-2 Weeks	201.0

Overview
catalog	abs136434
Description	The accumulation of blood leukocytes at inflammation sites is facilitated by a protein encoded by this gene. It is primarily found in cytokine-stimulated endothelial cells. The main function of this protein is to mediate the adhesion of cells to the vascular lining, thus aiding in leukocyte accumulation. It possesses distinct structural characteristics including lectin- and EGF-like domains, as well as short consensus repeat (SCR) domains with conserved cysteine residues. These features classify it as a member of the selectin family of cell adhesion molecules. Adhesion molecules play a crucial role in the interaction between leukocytes and the endothelium, and they are implicated in the development of atherosclerosis. [provided by RefSeq].
Other names	CD26E is a gene that encodes for the CD62 antigen-like family member E protein, also known as E-selectin or ELAM-1. This protein serves as an endothelial adhesion molecule and plays a crucial role in leukocyte adhesion to endothelial cells. CD26E is also referred to as LECAM2 or leukocyte-endothelial cell adhesion molecule 2. It is commonly denoted as LYAM2_HUMAN or simply Sele. The significance of this gene lies in its involvement in immune responses and inflammation pathways.
Source	Rabbit
Specificity	Endogenous levels of total SELE can be detected by SELE Antibody. Reorganizing the information, it can be restated as follows: The SELE Antibody is capable of identifying the total SELE levels that naturally occur within an organism.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Horse;Dog;
Antigen	SELE
Application	For Western blot, the recommended dilution range is 1:500-1:2000. For immunohistochemistry, the dilution range is 1:50-1:200. When using ELISA with a peptide, the recommended dilution range is 1:20000-1:40000. It is essential to follow these dilution ranges for accurate and reliable results in the experiments. Overdiluting or underdiluting the samples can greatly affect the outcome and compromise the validity of the experiment. Therefore, it is crucial to take caution and care when performing these techniques and adhere to the suggested dilution ranges.
Immunogen	A synthesized peptide derived from human SELE.
MW	67kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis.
Celluar localization	Cytoskeleton;Extracellular region or secreted;Plasma Membrane;
UniPort	P16581