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Rabbit Anti-SAR1A Polyclonal Antibody#abs139074

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Description

Catalog-specification	Delivery time	USD price
abs139074-100ug	1-2 Weeks	301.0
abs139074-50ug	1-2 Weeks	201.0

Overview
catalog	abs139074
Other names	The COPII-associated small GTPase, also known as SAR1a, is a GTP-binding protein involved in the regulation of protein transport within cells. Its full name is SAR1 homolog A (S. cerevisiae) and it is encoded by the SAR1A gene. SAR1a has various aliases, including Masra 2 and SARA 1. As a small GTPase, SAR1a serves as a molecular switch that cycles between an active, GTP-bound state and an inactive, GDP-bound state. This cycling is essential for the recruitment of COPII coat proteins to the surface of the endoplasmic reticulum (ER), which initiates the budding of transport vesicles. SAR1a is found in many different cell types and is widely expressed during development. Its homology to the SAR1 gene in yeast suggests that it has been evolutionarily conserved and is highly important for cellular function. Dysregulation or dysfunction of SAR1a has been implicated in various diseases, including neurodegenerative disorders and cancer. Overall, SAR1a plays a crucial role in regulating protein transport within cells, making it an important target for therapeutic interventions.
Source	Rabbit
Specificity	The detection of endogenous levels of total SAR1A can be achieved using SAR1A Antibody.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Rabbit;Pig;Sheep;Horse;Bovine
Antigen	SAR1A
Application	Based on the original text information, the recommended dilutions for WB, IHC, and ELISA are as follows: WB should be performed at a dilution of 1:1000-3000, IHC at a dilution of 1:200, and ELISA (peptide) at a dilution range of 1:20000-1:40000. It is important to note that these dilutions may vary depending on the specific experimental conditions and the antibodies used. Consequently, it is advisable to optimize the dilutions for each experiment accordingly.
Immunogen	A synthesized peptide derived from human SAR1A.
MW	22 kDa
Properties
Concentration	1mg/ml
purification	The SulfoLink™ Coupling Resin was used in peptide affinity chromatography to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain its properties, it is recommended to store the item at a temperature of -20 °C for a duration of one year. It is essential to avoid exposing it to repeated cycles of freezing and thawing. This will help to ensure that the item remains intact and usable.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Involved in transport from the endoplasmic reticulum to the Golgi apparatus (By similarity). Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES).
Celluar localization	Endoplasmic reticulum;Extracellular region or secreted;Golgi apparatus;
UniPort	Q9NR31