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Rabbit Anti-RNF19A Polyclonal Antibody#abs138237

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Catalog-specification	Delivery time	USD price
abs138237-100ug	1-2 Weeks	301.0
abs138237-50ug	1-2 Weeks	201.0

Dear valued customer,
We would like to inform you that the price mentioned above is for your reference only. For the detailed pricing, please contact our seller Vecent. We request you to kindly get in touch with our seller to obtain accurate pricing information.
Thank you for your understanding.
Best regards,
[Your Company Name]

Overview
catalog	abs138237
Other names	Dorfin, also known as RNF19A, is a double ring-finger protein that acts as an E3 ubiquitin-protein ligase. It is encoded by the gene DKFZP566B1346 and is also referred to as p38 or XYbp. Dorfin is involved in the process of ubiquitination, which is important for both protein degradation and signal transduction. The protein contains two RING finger domains, which are responsible for its function as a ubiquitin ligase. Dorfin may play an important role in the development and progression of certain diseases, such as Parkinson's disease, as it has been implicated in the degradation of abnormal proteins. Overall, better understanding of Dorfin's function may lead to new therapeutic strategies for these diseases.
Source	Rabbit
Specificity	The total RNF19A levels in the body are detected using the RNF19A Antibody, which is capable of recognizing endogenous levels of this protein. To generate similar content, one could rephrase the original information by stating that the RNF19A Antibody can detect the overall levels of RNF19A present in the body, regardless of their origin. This could be useful in research studies aimed at understanding the function of RNF19A or in clinical settings where the protein may be used as a diagnostic marker for certain diseases.
Species Reactivity	Human;Mouse
Predictive reaction species	Rabbit;Sheep;Dog;Horse;Bovine
Antigen	RNF19A
Application	The recommended dilution for WB is 1:1000-3000, while for IF/ICC it's 1:100-1:500. For ELISA using peptide, the suggested dilution is between 1:20000-1:40000. These dilutions ensure optimal results for detecting the target protein in various applications. It's crucial to follow the suggested dilution range to obtain accurate and reliable results.
Immunogen	A synthesized peptide derived from human RNF19A.
MW	90 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the purification of the antiserum was done through peptide affinity chromatography. Please recreate a similar content by rephrasing the original text, while ensuring that the content remains in line with the original information. While generating the content, ensure that you use a different approach to ChapGPT to avoid using similar phrases or words from the original text.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure the quality and stability of the product, it is recommended to store it at -20 °C for a period of one year. It is advised to avoid subjecting the product to multiple freeze/thaw cycles.
Storage buffer	The storage solution for Rabbit IgG includes phosphate buffered saline (pH 7.4), 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is recommended to store it at a temperature of -20 °C. The stability of the IgG is guaranteed for a period of 12 months starting from the date of its receipt.
Target
Background	E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection.
Tissue specificity	Widely expressed, with highest levels in heart. Ubiquitously expressed in the central nervous system.
Celluar localization	Cytoskeleton;Cytosol;
UniPort	Q9NV58