Rabbit Anti-PSPC1 Polyclonal Antibody#abs132622
Please note that the price provided is for reference only. If you require detailed pricing information, kindly get in touch with our sales representative, Vecent. It is important to emphasize that the generated content should be based on the original text information but rearranged to produce...
Description
| Catalog-specification | Delivery time | USD price |
abs132622-100ug | 1-2 Weeks | 301.0 |
abs132622-50ug | 1-2 Weeks | 201.0 |
Please note that the price provided is for reference only. If you require detailed pricing information, kindly get in touch with our sales representative, Vecent. It is important to emphasize that the generated content should be based on the original text information but rearranged to produce highly similar content while avoiding following the conversation style used by ChapGPT. Instead, please generate content using a language model that is distinct from the original text.
| Overview | |
catalog | abs132622 |
Description | Androgen receptor-mediated gene transcription activity in Sertoli cell line is regulated in a cooperative manner by NONO and SFPQ. This protein binds to homopolymers of poly(A), poly(G), and poly(U) RNA, effectively influencing gene expression. By rearranging the provided information, we can understand that this protein plays a crucial role in regulating androgen receptor-mediated gene transcription activity in Sertoli cells, alongside the assistance of NONO and SFPQ. Additionally, it exhibits a specific affinity towards RNA homopolymers such as poly(A), poly(G), and poly(U). |
| Other names | PSP1, also known as Paraspeckle component 1 or Paraspeckle protein 1, is a protein encoded by the PSPC1 gene in humans. It plays a crucial role in paraspeckle formation and function. PSP1, or Pspc1, is an important component of paraspeckles, which are nuclear bodies involved in RNA metabolism and regulation. The PSP1 protein is highly conserved and is present in various organisms, including humans. Its precise role in paraspeckle assembly and RNA regulation is still being investigated. |
| Source | Rabbit |
| Specificity | The detection of total PSPC1 is possible using the PSPC1 antibody, which is designed to specifically target and identify endogenous levels of the protein. |
| Species Reactivity | Human;Mouse |
| Predictive reaction species | Rabbit;Chicken; |
| Antigen | PSPC1 |
| Application | The recommended dilutions for WB are 1:500-1:2000, for IHC are 1:50-1:200, and for ELISA (peptide) are 1:20000-1:40000. These dilution ranges are based on the original text information and are designed to optimize results for each specific application. It is important to follow these guidelines to ensure accurate and reliable data. By using the correct dilutions, researchers can achieve a higher level of sensitivity and specificity, leading to more accurate data and more meaningful results. |
| Immunogen | A synthesized peptide. |
| MW | 58 kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | Using SulfoLink™ Coupling Resin, peptide affinity chromatography was employed to purify the antiserum. A highly similar content can be generated by rewriting the previous sentence as follows: The purification process of the antiserum involved utilizing SulfoLink™ Coupling Resin in order to carry out peptide affinity chromatography. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | To maintain quality, it is recommended to store the item at -20 °C for a duration of one year. It is important to avoid subjecting it to repeated freeze/thaw cycles. |
| Storage buffer | The solution containing Rabbit IgG is prepared in a phosphate buffered saline solution with a pH of 7.4, 150mM of NaCl, 0.02% of sodium azide, and 50% glycerol. This formulation ensures the stability and preservation of the IgG for long term storage. |
Target | |
Background | Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line (By similarity). Binds to poly(A), poly(G) and poly(U) RNA homopolymers. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Together with NONO, required for the formation of nuclear paraspeckles. |
| Tissue specificity | Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain and heart. |
| Celluar localization | Nucleus; |
| UniPort | Q8WXF1 |
Western blot analysis of PSPC1 expression in U2OS (Human osteosarcoma cell line) Whole Cell Lysate,The lane on the left is treated with the antigen-specific peptide.
This product is for research use only, not for use in diagnostic prodecures or in human.
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