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Rabbit Anti-PSMC2 Polyclonal Antibody#abs136256

Please note that the price provided is only for your reference. For more detailed pricing information, we recommend that you contact our seller Vecent. Thank you. Western blot analysis of extracts of various celllines, using PSMC2 antibody. This product is for research use only, not for use in...

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Description

Catalog-specification	Delivery time	USD price
abs136256-100ug	1-2 Weeks	301.0
abs136256-50ug	1-2 Weeks	201.0

Please note that the price provided is only for your reference. For more detailed pricing information, we recommend that you contact our seller Vecent. Thank you.

Overview
catalog	abs136256
Description	The 26S proteasome is a well-structured multicatalytic proteinase complex that consists of two main components: the 20S core and the 19S regulator. The 20S core is made up of four rings, with each ring containing seven non-identical subunits. Specifically, two rings consist of alpha subunits and the other two rings consist of beta subunits. Complementing the 20S core, the 19S regulator is composed of two parts: the base and the lid. The base comprises six ATPase subunits and two non-ATPase subunits, while the lid can contain up to ten non-ATPase subunits. These components work together to regulate the proteasome's activity. Proteasomes are found in abundance within eukaryotic cells and play a crucial role in peptide cleavage. This process relies on an ATP/ubiquitin-dependent mechanism, which takes place outside of lysosomes. One specific variant of proteasome, known as the immunoproteasome, is modified to facilitate the processing of class I MHC peptides. Within this context, the gene mentioned in the text encodes an ATPase subunit belonging to the triple-A family of ATPases. These ATPase subunits have chaperone-like activities. This particular subunit has been observed to interact with basal transcription factors, suggesting its involvement in transcription regulation. Additionally, it has the potential to compete with another subunit called PSMC3 in binding to the HIV tat protein, thereby influencing the interaction between the viral protein and the transcription complex. It is worth noting that alternative splicing contributes to the production of multiple transcript variants, each encoding distinct isoforms of this gene.
Other names	26S protease complex plays a crucial role in protein degradation within cells. One of its regulatory subunits, 26S protease regulatory subunit 7, also known as PRS7_HUMAN or MSS1, interacts with the proteasome AAA-ATPase subunit RPT1. This interaction is important for the proper functioning of the complex. Additionally, there is a putative protein product of Nbla10058 that is thought to be involved in suppressing the function of sgv-1 in yeast. The 26S proteasome is a large protein complex responsible for degrading damaged or unwanted proteins. Within this complex, the 26S protease subunit 7, also known as protease 26S subunit 7, interacts with the ATPase subunit 2, also known as proteasome 26S ATPase subunit 2 or PSMC2. This interaction is necessary for the ATP-dependent unfolding and translocation of the substrates into the proteasome for degradation. The protein MSS1 plays a regulatory role in this process. In summary, the 26S protease complex is composed of various subunits, including the regulatory subunit 7 and the ATPase subunit 2. These subunits work together to ensure efficient protein degradation and maintain cellular homeostasis. Furthermore, MSS1 and the putative protein product of Nbla10058 are implicated in modulating the activity of this complex.
Source	Rabbit
Specificity	The PSMC2 Antibody is capable of identifying total PSMC2 at natural levels within an organism. A new piece of writing based on this information would need to convey the same message, but in a unique and unreplicated way.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Zebrafish;Chicken;Rabbit;Xenopus;Dog;Horse;Bovine;Sheep;Pig
Antigen	PSMC2
Application	WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human PSMC2.
MW	48kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
Celluar localization	Cytosol;Extracellular region or secreted;Nucleus;
UniPort	P35998