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Rabbit Anti-PRRX1 Polyclonal Antibody#abs134576

Rabbit Anti-PRRX1 Polyclonal Antibody#abs134576

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Description

Catalog-specificationDelivery timeUSD price

abs134576-100ug

1-2 Weeks

301.0

abs134576-50ug

1-2 Weeks

201.0

Please note that the price mentioned above is for your reference only. For detailed pricing information, please get in touch with our seller Vecent. Please be advised that the content I am about to generate will be significantly different from the original text, as it is based on a language model and not on specific dialogue generation techniques.


Overview

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abs134576
Other namesAGOTC; Homeobox protein PHOX1 is also known as Paired mesoderm homeo box 1. It is a transcription factor that plays a crucial role in development and differentiation processes. The gene encoding PHOX1 is called PRRX1 (Paired-related homeobox 1).
PHOX1 is a member of the homeobox gene family, which controls the expression of other genes by binding to specific DNA sequences. It is involved in various biological processes, including embryogenesis, organogenesis, and tissue regeneration.
The protein encoded by PHOX1 is characterized by a DNA-binding domain called the homeodomain. The homeodomain enables PHOX1 to bind to specific DNA sequences and regulate the transcription of target genes. In particular, PHOX1 regulates the expression of genes involved in mesoderm development, such as genes responsible for cell proliferation, migration, and morphogenesis.
The expression of PHOX1 is tightly regulated during development and is spatially and temporally restricted. It is expressed in various tissues, including the developing heart, limb buds, and craniofacial structures. The precise regulation of PHOX1 expression is essential for proper development and differentiation of these tissues.
Furthermore, studies have shown that mutations or dysregulation of PHOX1 can lead to developmental abnormalities and contribute to human diseases. For example, mutations in the PHOX1 gene have been associated with craniofacial defects, including cleft lip and palate.
In conclusion, PHOX1 is a critical transcription factor involved in the regulation of development and differentiation processes. Its precise expression and function are crucial for proper embryogenesis and organogenesis. Further research on PHOX1 is necessary to fully understand its role in development and its potential implications in human health and disease.
SourceRabbit
SpecificityTotal PRRX1 levels can be effectively detected by PRRX1 Antibody, which specifically binds to endogenous PRRX1. By utilizing this antibody, researchers can accurately measure the overall expression of PRRX1 in biological samples. The antibody's capability in recognizing the endogenous levels of total PRRX1 enables efficient analysis and understanding of PRRX1's role in various biological processes. With this detection tool, scientists gain valuable insights into the functioning and significance of PRRX1 in different contexts.
Species ReactivityHuman;Mouse;Rat
Predictive reaction speciesChicken;Rabbit;Pig;Dog;Horse;Bovine;
AntigenPRRX1
Application（IF/ICC）（IF/ICC）1:100-1:500。（ELISA）1:20000-1:40000。，WB，1:500-1:1000。，。
ImmunogenA synthesized peptide.
MW27 KD
Properties

Concentration

1mg/ml

purificationUsing SulfoLink™ Coupling Resin, the antiserum underwent peptide affinity chromatography purification. The resulting product is highly purified and has a similar structure to the original antiserum.
ClonalityPolyclonal Antibody
Stability & StorageTo guarantee optimal storage conditions, it is recommended to keep the product at a temperature of -20 °C for a period of one year. The product should not be subjected to repeated freeze/thaw cycles as this may compromise its quality and efficacy. It is important to follow these storage instructions in order to ensure the stability and effectiveness of the product over time.
Storage bufferRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.

Target

Background

Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer (By similarity).

Celluar localizationNucleus;
UniPortP54821


This product is for research use only, not for use in diagnostic prodecures or in human.


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