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Rabbit Anti-PRKX Polyclonal Antibody#abs134775

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Description

Catalog-specification	Delivery time	USD price
abs134775-100ug	1-2 Weeks	301.0
abs134775-50ug	1-2 Weeks	201.0

Overview
catalog	abs134775
Other names	Protein kinase PKX1, also known as PRKX or PRKX_HUMAN, is an important enzyme involved in cellular signaling pathways. It belongs to the serine/threonine-protein kinase family and plays crucial roles in various biological processes. PRKX, an abbreviation for protein kinase PKX1, exhibits high similarity with other protein kinases. Its function revolves around the regulation and phosphorylation of proteins, ultimately influencing cellular activities. Protein kinase PKX1 acts as a catalyst, transferring phosphate groups from ATP molecules to specific target proteins. This post-translational modification, known as phosphorylation, often modulates the function and activity of target proteins. By participating in key signaling cascades, PRKX controls essential cellular processes such as cell division, differentiation, and survival. The human PRKX gene encodes the PRKX protein kinase, which is expressed in various tissues and cells throughout the body. Emerging studies have implicated PRKX in multiple cellular pathways, including the regulation of transcription, cell cycle progression, and apoptosis. Dysregulation of PRKX activity has been associated with several diseases, including cancer, cardiovascular disorders, and developmental defects. Understanding the structure and function of PRKX provides valuable insights into its potential as a therapeutic target. Efforts are being made to design selective PRKX inhibitors that could be utilized in the treatment of various diseases. Additionally, extensive research is underway to unravel the intricate signaling networks involving PRKX and its interactors. In conclusion, protein kinase PKX1, commonly referred to as PRKX, is a serine/threonine-protein kinase that exerts significant control over cellular processes. Its phosphorylation activities and involvement in diverse signaling pathways make it a crucial player in numerous biological events. Continued investigation into the role of PRKX promises to uncover novel therapeutic strategies and enhance our understanding of fundamental cellular mechanisms.
Source	Rabbit
Specificity	The detection capability of the PRKX Antibody extends to the measurement of endogenous levels of total PRKX protein. To maintain accuracy, it is essential to rearrange the content and present it in a different form.
Species Reactivity	Human;Mouse;Rat
Antigen	PRKX
Application	Sure, I can provide similar content based on the original text information. For western blot, the recommended dilution range is 1:500 to 1:1000, while for immunohistochemistry, it is advised to use a dilution of 1:50 to 1:200. For immunofluorescence and immunocytochemistry, the dilution should be within the range of 1:100 to 1:500. In ELISA using peptide as the antigen, the suggested dilution range would be 1:20000 to 1:40000. We have found these dilution ranges to be optimal for detecting the target protein with high specificity and sensitivity.
Immunogen	A synthesized peptide.
MW	41 KD
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. A highly refined product was achieved through this method.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the quality of the product, it is recommended to store it at a temperature of -20°C for a period of one year. To avoid potential damage, it is important to refrain from subjecting the product to repeated cycles of freezing and thawing. By following these guidelines, you can ensure that the product remains usable for an extended period of time.
Storage buffer	This product contains Rabbit IgG in a phosphate buffered saline solution with a pH of 7.4. It also contains 150mM NaCl, 0.02% sodium azide, and 50% glycerol. For optimal preservation, it is recommended to store at a temperature of -20 °C. This product is stable for a period of 12 months from the date of its receipt.
Target
Background	This protein is a serine/threonine kinase that plays a critical role in cell signaling mediated by cAMP. Through phosphorylation of downstream targets such as CREB, SMAD6, and PKD1, this kinase is involved in several important cellular processes including differentiation and morphogenesis. In particular, it regulates myeloid cell differentiation via SMAD6 phosphorylation and promotes renal epithelial cell migration and tubulogenesis during nephrogenesis. The kinase also stimulates angiogenesis by promoting endothelial cell proliferation, migration, and the formation of vascular-like structures. Overall, this protein serves as a key mediator of cAMP signaling and plays a central role in various physiological processes.
Tissue specificity	Widely expressed (at protein level). Specifically expressed in blood by macrophages and granulocytes according to PubMed:9860982.
Posttranslational modification	Phosphorylated; autophosphorylates in vitro.
Celluar localization	Nucleus;
UniPort	P51817