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Rabbit Anti-POLR3E Polyclonal Antibody#abs140520

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Description

Catalog-specification	Delivery time	USD price
abs140520-100ug	1-2 Weeks	301.0
abs140520-50ug	1-2 Weeks	201.0

Overview
catalog	abs140520
Other names	The DNA-directed RNA polymerase III consists of several subunits, including the 80 kDa polypeptide, also known as subunit RPC5 or C5. This important enzyme is responsible for transcribing different types of RNA molecules, including tRNAs, 5S rRNA, and other structural RNAs. The human gene encoding the 80 kDa polypeptide is also known as KIAA1452 or FLJ10509 and is often referred to as POLR3E. Through its interaction with other subunits, POLR3E plays a crucial role in the accurate initiation and elongation of RNA synthesis. Research on this essential enzyme is ongoing, as it has important implications for understanding the regulation of gene expression and the mechanisms of various diseases.
Source	Rabbit
Specificity	The total POLR3E levels can be identified by the POLR3E Antibody, which effectively detects the endogenous levels of this protein. To create similar content based on the original text information, we can present it as follows: "By employing the POLR3E Antibody, one can accurately detect the endogenous levels of total POLR3E protein."
Species Reactivity	Human
Predictive reaction species	Pig;Sheep;Bovine;Horse;
Antigen	POLR3E
Application	WB 1:1000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human POLR3E.
MW	80kDa
Properties
Concentration	1mg/ml
purification	The SulfoLink™ Coupling Resin was employed in the peptide affinity chromatography procedure to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure the stability of the product, it is recommended to store it at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting it to multiple freeze/thaw cycles during storage.
Storage buffer	The Rabbit IgG is stored in a solution of phosphate buffered saline with a pH of 7.4. It contains 150mM NaCl, 0.02% sodium azide, and 50% glycerol. The recommended storage temperature is -20 °C, and it remains stable for up to 12 months from the date of receipt.
Target
Background	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).
Celluar localization	Cytosol;Nucleus;
UniPort	Q9NVU0