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Rabbit Anti-PINX1 Polyclonal Antibody#abs138378

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Description

Catalog-specification	Delivery time	USD price
abs138378-100ug	1-2 Weeks	301.0
abs138378-50ug	1-2 Weeks	201.0

Dear Customer,
Please note that the price mentioned above is for your reference only. For the detailed price quote, kindly get in touch with our seller Vecent. We would be happy to assist you with any queries or concerns you may have.
Thank you for choosing our services.
Best regards,
[Your name]

Overview
catalog	abs138378
Other names	The protein 67-11-3, also known as FLJ20565, is a putative tumor suppressor that is closely associated with hepatocellular carcinoma and liver-related malignancies. It is also referred to as the liver-related putative tumor suppressor (LPTS) or LPTL. Other aliases for this protein include PIN2 interacting protein 1, and PIN2/TERF1-interacting telomerase inhibitor 1 (PINX1). The PINX1 protein plays an important role in regulating telomerase activation and function in normal and cancerous cells. The 67-11-3 protein is encoded by the MGC8850 gene and is highly conserved across different species. It interacts with two important proteins, PIN2 and TRF1, which are involved in telomere maintenance and telomerase regulation respectively. The PINX1 protein binds to PIN2, an important telomere-binding protein, and inhibits its interaction with TRF1. This effectively blocks telomerase activation and telomere elongation, which are critical for cancer cell growth and proliferation. Recent studies have identified the 67-11-3 protein as a potential biomarker for liver cancer diagnosis and prognosis. The expression levels of this protein are significantly downregulated in liver cancer tissues compared to normal liver tissues. This suggests that the 67-11-3 protein may play a crucial role in preventing liver cancer development and progression. Further research is needed to fully elucidate the molecular mechanisms underlying the functions of this protein.
Source	Rabbit
Specificity	The total PINX1 levels in the body can be detected using the PINX1 antibody, which targets the endogenous levels. To create similar content, the given text can be rephrased as follows: The endogenous levels of total PINX1 can be easily detected using the PINX1 antibody. It accurately detects the presence of PINX1 in the body.
Species Reactivity	Human
Predictive reaction species	Rabbit
Antigen	PINX1
Application	The dilutions for WB range from 1:1000 to 1:3000, while for IHC it is 1:200. The peptide dilution for ELISA is between 1:20000 and 1:40000. To maintain the original information, here is another version: The dilution ratios for Western blot (WB) assay vary from 1:1000 to 1:3000, for immunohistochemistry (IHC) it is 1:200, and for ELISA using peptides it ranges from 1:20000 to 1:40000.
Immunogen	A synthesized peptide derived from human PINX1.
MW	37 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was employed in the process of purifying the antiserum through peptide affinity chromatography. The purification method involved utilizing SulfoLink™ Coupling Resin to separate and isolate the desired components of the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the quality of the product, it is recommended to keep it at a temperature of -20°C for a duration of one year. It is important to avoid subjecting the product to repeated cycles of freezing and thawing. This will help to ensure that the product maintains its integrity over time.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor.
Tissue specificity	Ubiquitous; expressed at low levels. Not detectable in a number of hepatocarcinoma cell lines.
Celluar localization	Cytoskeleton;Nucleus;
UniPort	Q96BK5