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Rabbit anti-OPRL1 Polyclonal Antibody#abs133213

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Description

Catalog-specification	Delivery time	USD price
abs133213	1-2 Weeks	201
abs133213	1-2 Weeks	301

Overview
Description	The nociceptin/orphanin FQ receptor is responsible for responding to the neuropeptide of the same name. This receptor plays a crucial role in regulating many important brain functions related to instinctual behaviors and emotional responses. Through the inhibition of adenylyl cyclase with the use of G proteins, the activity of this receptor is mediated and able to effectively modulate these processes.
Other names	The human mRNA for the ORL1 receptor, also known as Kappa type 3 opioid receptor, KOR 3, LC132 receptor like, MGC34578, Nociceptin receptor, NOCIR, NOP, OOR, Opiate receptor like 1, Oprl1, OPRX_HUMAN, ORL1, or Orphanin FQ receptor, plays a crucial role in our understanding of this important receptor. The ORL1 receptor, belonging to the opioid receptor family, is involved in nociception and the binding of nociceptin/orphanin FQ (N/OFQ) peptide. It shares homology with the rat LC132 receptor and is considered a rat homolog. Its function and importance in mediating pain signaling make it a target for potential therapeutics. The detailed characterization and further investigation of this receptor are necessary to unravel its full potential in pain modulation and associated disorders.
Source	Rabbit
Specificity	The OPRL1 antibody can identify total OPRL1 that occurs naturally within the body. This means that it has the capability to detect the entire range of OPRL1 that can be found in the body.
Species Reactivity	Human;Mouse;Rat
Antigen	OPRL1
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	41 kDa;
Properties
Concentration	1mg/ml
purification	We employed SulfoLink™ Coupling Resin in the process of peptide affinity chromatography to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure proper storage, keep the item at a temperature of -20 °C for a duration of one year. It is crucial to avoid subjecting it to multiple freezing and thawing cycles during this time.
Storage buffer	The composition of the solution contains rabbit IgG suspended in a phosphate buffered saline solution with a pH of 7.4, 150mM of sodium chloride, 0.02% of sodium azide and 50% glycerol for preservation.
Target
Background	The G-protein coupled opioid receptor acts as a receptor for nociceptin, an endogenous neuropeptide. Ligand binding to this receptor induces a conformational change that stimulates signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Moreover, activation of G proteins leads to the inhibition of adenylate cyclase and calcium channel activity. In addition, the activity of arrestins helps to regulate signaling via G proteins and facilitates the activation of alternative signaling pathways that result in the activation of MAP kinases. This receptor plays a vital role in the modulation of nociception and pain perception. Furthermore, it also contributes to the regulation of locomotor activity by the neuropeptide nociceptin.
Tissue specificity	Detected in blood leukocytes.
Posttranslational modification	Phosphorylation at Ser-363 requires GRK3.
Celluar localization	Plasma Membrane;
UniPort	P41146