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Rabbit Anti-METAP2 Polyclonal Antibody#abs137883

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Description

Catalog-specification	Delivery time	USD price
abs137883-100ug	1-2 Weeks	301.0
abs137883-50ug	1-2 Weeks	201.0

Overview
catalog	abs137883
Other names	A930035J23Rik is a gene also known as AI047573, AL024412, Amp2, and AU014659. It encodes a protein called EIF 2 associated p67 homolog or EIF-2-associated 67 kDa glycoprotein. This protein is involved in the initiation of protein synthesis and is crucial for cellular function. Additionally, it is known by other names such as MAP 2, MetAP 2, Methionine aminopeptidase 2, and p67eIF2. The gene has several aliases, including MGC102452, MGC127390, MGC53792, and MNPEP. Overall, A930035J23Rik plays a role in peptidase M2 activity and is an important component of cellular processes.
Source	Rabbit
Specificity	The detection of total METAP2 at endogenous levels can be achieved using the METAP2 Antibody.
Species Reactivity	Human
Predictive reaction species	Chicken;Rabbit;Pig;Dog;Sheep;Horse;Bovine
Antigen	METAP2
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human METAP2.
MW	52 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum was subjected to peptide affinity chromatography for purification.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure optimal storage, it is recommended to keep the store at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the items to recurring freeze/thaw cycles.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo.
Posttranslational modification	Contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. O-glycosylation is required for EIF2S1 binding.
Celluar localization	Cytosol;Plasma Membrane;
UniPort	P50579