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Rabbit Anti-MAP3K7IP1 Polyclonal Antibody#abs136983

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Description

Catalog-specification	Delivery time	USD price
abs136983-100ug	1-2 Weeks	301.0
abs136983-50ug	1-2 Weeks	201.0

Overview
catalog	abs136983
Description	This gene encodes a protein that acts as a regulator for the MAP kinase kinase kinase MAP3K7/TAK1, known for its involvement in various intracellular signaling pathways triggered by TGF beta, interleukin 1, and WNT-1. By interacting with TAK1 kinase, this protein facilitates its activation. Studies have revealed that the C-terminal region of the protein alone is sufficient to bind and activate TAK1, while a section of the N-terminus acts as a dominant-negative inhibitor of TGF beta. This suggests that the protein may serve as a mediator bridging TGF beta receptors and TAK1. Additionally, it can interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), providing an alternative pathway for MAPK14's biological responses to diverse stimuli. Multiple transcript variants encoding distinct isoforms of this protein have been identified through alternative splicing mechanisms.
Other names	The human gene 2310012M03Rik is also known as TAB1, TAK1-binding protein 1 or Transforming growth factor beta activated kinase binding protein 1. It encodes for the protein Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 (MAP3K7IP1), which is crucial in the activation of the TGF-beta activated kinase 1 (TAK1) pathway. TAB1 works by binding with TAK1, which results in the activation of downstream effectors involved in cellular stress responses, inflammation, and immune responses. Additionally, TAB1 is involved in regulating cell survival, differentiation, and proliferation through various signaling pathways, including the MAPK/ERK and NF-kappaB pathways. The human protein TAB1 is an essential component of the TAK1 signaling cascade and may be a potential target for the treatment of various diseases associated with aberrant TAK1 activity.
Source	Rabbit
Specificity	The MAP3K7IP1 Antibody is capable of detecting total levels of endogenous MAP3K7IP1 protein. We can produce a closely related version of this information by reorganizing the original text and making sure that the generated content remains true to the original information.
Species Reactivity	Human;Mouse;Rat
Antigen	MAP3K7IP1
Application	The dilution ratios for Western Blot (WB) range from 1:500 to 1:2000, for Immunohistochemistry (IHC) range from 1:50 to 1:200, and for ELISA (peptide) range from 1:20000 to 1:40000. These dilution ranges are commonly used in laboratory experiments and assays. It is important to carefully follow these dilution guidelines to ensure accurate and reliable results. Whether you are conducting WB, IHC, or ELISA with peptide antigens, maintaining the appropriate dilution ratios is crucial for the success of your experiments. Make sure to properly adjust your sample and antibody concentrations within these ranges to achieve optimal staining and detection.
Immunogen	MAP3K7IP1 is a crucial human protein, and a synthesized peptide derived from it holds immense potential. Its structure and sequence are carefully designed to resemble that of MAP3K7IP1, ensuring high similarity and effectiveness. Reordering and combining the original text information, I present another way to describe this synthesized peptide: The synthesized peptide, originating from human MAP3K7IP1, delivers significant value due to its carefully designed structure and sequence. With a composition that closely resembles MAP3K7IP1, this peptide exhibits exceptional potential and effectiveness. Through meticulous rearrangement, this alternative description showcases the unique attributes of this synthesized peptide.
MW	54kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.
Tissue specificity	Ubiquitous.
Posttranslational modification	Monoubiquitinated. Deubiquitinated by Y.enterocolitica YopP.
Celluar localization	Cytosol;Endosome;Nucleus;
UniPort	Q15750