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Rabbit Anti-ITGA8 Polyclonal Antibody#abs138513

Please note that the mentioned price is provided for your reference only. For the detailed pricing information, we kindly request you to reach out to our seller, Vecent. Western blot analysis ITGA8 using LOVO whole cell lysates This product is for research use only, not for use in diagnostic...

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Description

Catalog-specification	Delivery time	USD price
abs138513-100ug	1-2 Weeks	301.0
abs138513-50ug	1-2 Weeks	201.0

Please note that the mentioned price is provided for your reference only. For the detailed pricing information, we kindly request you to reach out to our seller, Vecent.

Overview
catalog	abs138513
Other names	The protein known as Integrin alpha 8 is a complex made up of both heavy and light chains. Specifically, it is composed of Integrin alpha-8 heavy chain and Integrin alpha-8 light chain, which together form the ITGA8 molecule. This protein plays an important role in cell adhesion and the formation of blood vessels. Scientists refer to this molecule as ITA8_HUMAN, though it is also commonly referred to as Integrin alpha-8 or simply ITGA8. Overall, Integrin alpha 8 is a crucial component of many physiological processes in the human body.
Source	Rabbit
Specificity	The ITGA8 Antibody is capable of detecting the total endogenous levels of ITGA8. To convey the same information, the generated content may read as follows - Total levels of endogenous ITGA8 can be detected using the ITGA8 Antibody.
Species Reactivity	Human;Mouse
Antigen	ITGA8
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human ITGA8.
MW	117 kDa
Properties
Concentration	1mg/ml
purification	By utilizing SulfoLink™ Coupling Resin, the purification of the antiserum was achieved through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To keep for a year, store at a temperature of -20°C. Make sure to avoid numerous cycles of freezing and thawing. It's important to note that this information is based on the original text.
Storage buffer	This sample contains Rabbit IgG in a solution of phosphate buffered saline with a pH of 7.4, 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It should be stored at a temperature of -20 °C and will remain stable for a period of 12 months from the date of reception.
Target
Background	Integrin alpha-8/beta-1 plays a crucial role in the development of kidney and potentially other organs. Its primary function is to control the recruitment of mesenchymal cells into epithelial structures. This integrin specifically recognizes the R-G-D sequence present in various ligands such as TNC, FN1, SPP1 TGFB1, TGFB3, and VTN. In the kidney development process, NPNT is believed to be its functional ligand. Furthermore, this integrin serves as the neuronal receptor for TNC, facilitating cell-cell interactions and regulating the growth of sensory and motor neurons' neurites. Rearranging the given content while retaining the original information, it can be said that Integrin alpha-8/beta-1 is a critical regulator in the formation of organs, particularly the kidney, by governing the inclusion of mesenchymal cells into epithelial structures. Its extensive ligand recognition encompasses TNC, FN1, SPP1 TGFB1, TGFB3, and VTN, epitomized by the recognition of the R-G-D sequence. While NPNT is likely the functional ligand responsible for kidney development, this integrin also serves as the neuronal receptor for TNC, enabling cell-cell interactions and influencing neurite outgrowth in sensory and motor neurons.
Tissue specificity	Expressed in mesenchymal cells, including alveolar myofibroblasts, kidney mesangial cells and hepatic stellar cells and vascular and visceral smooth muscle (at protein level).
Celluar localization	Endoplasmic reticulum;Plasma Membrane;
UniPort	P53708