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Rabbit Anti-IL23R Polyclonal Antibody#abs136021

Please note that the mentioned price is only for your reference. For specific pricing details, we kindly advise you to get in touch with our dedicated seller, Vecent. Western blot analysis of extracts of various celllines, using IL23R antibody. This product is for research use only, not for use...

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Description

Catalog-specification	Delivery time	USD price
abs136021-100ug	1-2 Weeks	301.0
abs136021-50ug	1-2 Weeks	201.0

Please note that the mentioned price is only for your reference. For specific pricing details, we kindly advise you to get in touch with our dedicated seller, Vecent.

Overview
catalog	abs136021
Description	The IL23A/IL23 receptor consists of this gene's protein subunit. It forms a complex with IL12RB1/IL12Rbeta1, which is essential for IL23A signaling. This protein constantly interacts with Janus kinase 2 (JAK2) and can also specifically bind to a transcription activator called STAT3 in the presence of a ligand. This information is sourced from RefSeq, and the content created has been rearranged for clarity while maintaining the original information.
Other names	The IL-23R, also known as IL-23 receptor or IL23R, is an important protein involved in immune responses. It plays a crucial role in mediating the effects of interleukin 23 (IL-23), a cytokine that regulates inflammation and immune cell function. The IL-23R protein, encoded by the IL23R gene, is expressed on the surface of various immune cells, such as T cells and natural killer cells. Understanding the IL-23R is essential because it influences the body's immune response to infections and autoimmune diseases. Studies have shown that genetic variations in the IL23R gene can impact the susceptibility to certain diseases, including inflammatory bowel disease (IBD), psoriasis, and ankylosing spondylitis. The IL-23R protein functions by binding to IL-23, which triggers a cascade of signaling events that activate immune cells and promote inflammation. This activation is necessary for the body's defense against pathogens but can also contribute to chronic inflammation and autoimmune disorders when dysregulated. Researchers are actively studying IL-23R and its role in various diseases to develop targeted therapies. Blocking IL-23R signaling has shown promising results in the treatment of autoimmune conditions like psoriasis, with several biologic drugs targeting IL-23 or IL-23R already approved by regulatory agencies. In conclusion, the IL-23R is an essential receptor involved in the immune response and the development of autoimmune diseases. Further understanding of this receptor could lead to improved treatment options for individuals affected by immune-related disorders.
Source	Rabbit
Specificity	The IL23R Antibody is capable of detecting overall IL23R levels that are present endogenously. To create new content using the same information, we can say that the IL23R Antibody accurately detects the total amount of IL23R present within an organism.
Species Reactivity	Human;Mouse;Rat
Antigen	IL23R
Application	WB，1:5001:2000；IHC，1:501:200；ELISA（），1:200001:40000。，。
Immunogen	A synthesized peptide derived from human IL23R.
MW	69kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was used to perform peptide affinity chromatography and purify the antiserum. The resulting purification process resulted in a highly refined and concentrated product.
Clonality	Polyclonal Antibody
Stability & Storage	One should store the item at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the item to repeated freeze/thaw cycles to maintain its quality.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.
Tissue specificity	Expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells.
Posttranslational modification	Phosphorylated in response to IL23.
Celluar localization	Plasma Membrane;
UniPort	Q5VWK5