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Rabbit Anti-HES6 Polyclonal Antibody#abs138184

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Description

Catalog-specification	Delivery time	USD price
abs138184-100ug	1-2 Weeks	301.0
abs138184-50ug	1-2 Weeks	201.0

Overview
catalog	abs138184
Other names	Hairy and enhancer of split 6, also known as HES6, is a transcription cofactor belonging to the class B basic helix-loop-helix (bHLH) protein family. It is the homolog of Hairy/enhancer of split 6 in Drosophila. Another name for HES6 is C HAIRY1. HES6 plays a crucial role in various biological processes and gene regulation. It is involved in the development and differentiation of cells. The bHLH transcription factor 6, HES6, is an important component in cellular pathways and serves as a transcriptional regulator. Its functions and mechanisms are still being extensively studied in the context of gene expression and development.
Source	Rabbit
Specificity	The HES6 Antibody is specifically designed to identify the presence of total HES6 protein in its natural state within the organism. It is capable of recognizing endogenous levels of HES6, providing accurate and reliable results. Therefore, the antibody allows for the detection and analysis of the overall expression of HES6 protein in biological samples. With the ability to detect total HES6, this antibody serves as a valuable tool for investigating the role and function of HES6 in various biological processes.
Species Reactivity	Human
Antigen	HES6
Application	For Western Blotting applications, the recommended dilutions are 1:1000-3000. With Immunofluorescence/Immunocytochemistry applications, the recommended dilutions are 1:100-1:500. For ELISA assays using a peptide substrate, the recommended dilutions range from 1:20000-1:40000. It's important to follow these recommended dilutions to ensure accurate and reliable results from your experiments.
Immunogen	A synthesized peptide derived from human HES6.
MW	24 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent a process of peptide affinity chromatography to achieve purification. This ensured that the final product was of high quality and suitable for use in various applications.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure proper storage, keep the item at a temperature of -20°C for a period of one year. It is important to avoid any instances of freezing and thawing, as this can damage the item. Please take care to properly follow these instructions to maintain the quality of the product.
Storage buffer	This product contains Rabbit IgG in a phosphate buffered saline solution at a pH of 7.4, with 150mM NaCl and 0.02% sodium azide as well as 50% glycerol. For optimal storage, keep at a temperature of -20 °C and it should remain stable for up to 12 months from the date of receipt.
Target
Background	Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation (By similarity).
Celluar localization	Nucleus;
UniPort	Q96HZ4