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Rabbit Anti-STAG3 Polyclonal Antibody#abs133772

Description

Catalog-specification	Delivery time	USD price
abs133772-100ug	1-2 Weeks	301.0
abs133772-50ug	1-2 Weeks	201.0

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Overview
catalog	abs133772
Other names	Stromal Antigen 3, also known as Cohesin subunit SA3 or SCC3 homolog 3, is a crucial protein that plays a vital role in chromosome segregation during cell division. This protein is a subunit of the cohesin complex, which maintains the cohesion between sister chromatids. SA3 is essential for proper chromosome alignment and segregation during both mitosis and meiosis, and any errors in this process can result in chromosome abnormalities and even cell death. Mutations in the SA3 gene have been associated with various human diseases, including cancer and developmental disorders. Therefore, understanding the function and regulation of SA3 is critical for the development of new therapies for these diseases.
Source	Rabbit
Specificity	Total STAG3 can be detected by the STAG3 Antibody at endogenous levels.
Species Reactivity	Human
Antigen	STAG3
Application	The recommended dilution for WB is between 1:500 to 1:1000, for IF/ICC it is between 1:100 to 1:500, and for ELISA (peptide) it is between 1:20000 to 1:40000. To ensure the accuracy of the results, it is important to strictly follow these dilution recommendations. These dilution ratios are based on the original text information and are essential for achieving reliable and reproducible results in your assays. So, be sure to dilute your samples appropriately before running any experiments.
Immunogen	A synthesized peptide.
MW	139 KD
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was used for peptide affinity chromatography to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the integrity of the product, it is recommended to store it at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the product to repeated cycles of freezing and thawing, as this could compromise its quality and efficacy. By following these storage guidelines, you can ensure that the product remains stable and effective for its intended use.
Storage buffer	The recommended storage condition for Rabbit IgG is at -20 °C in phosphate buffered saline with a pH of 7.4. The solution contains 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is advised to store it for up to 12 months from the date of receipt to maintain its stability.
Target
Background	The cohesin complex, a crucial element in meiosis, plays a specific role in ensuring the cohesion of sister chromatids following DNA replication. This intricate complex is responsible for forming a large protein ring structure that effectively entraps the sister chromatids. As the cell progresses to anaphase, the cohesin complex undergoes cleavage and dissociates from the chromatin, enabling the segregation of sister chromatids. However, during prophase I of meiosis, it is believed that the meiosis-specific cohesin complex takes over the role of its mitosis-specific counterpart by replacing it upon dissociation from the chromatin. This switch in cohesin complex is vital for the successful progression of meiosis and the proper separation of genetic material.
Tissue specificity	Testis specific.
Posttranslational modification	Phosphorylated.
Celluar localization	Extracellular region or secreted;Nucleus;
UniPort	Q9UJ98